Selective GABAA circuits for novel CNS drugs

H. Möhler; U. Rudolph

doi:10.1016/j.ddstr.2004.08.019

Selective GABA_A circuits for novel CNS drugs

Research output: Contribution to journal › Review article › peer-review

Abstract

By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in brain function. GABAergic interneurons are highly diverse. The respective γ-aminobutyric acid (GABA)_A receptor subtypes, therefore, provide new opportunities for targeting selective neuronal circuits. In addition, multiple sites for drug interactions are present on GABA_A receptor subtypes. Their pharmacological relevance is increasingly being recognized. A new central nervous system (CNS) pharmacology is on the horizon.

Original language	English (US)
Pages (from-to)	117-123
Number of pages	7
Journal	Drug Discovery Today: Therapeutic Strategies
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.ddstr.2004.08.019
State	Published - Sep 2004
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

Online availability

10.1016/j.ddstr.2004.08.019

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Cite this

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abstract = "By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in brain function. GABAergic interneurons are highly diverse. The respective γ-aminobutyric acid (GABA)A receptor subtypes, therefore, provide new opportunities for targeting selective neuronal circuits. In addition, multiple sites for drug interactions are present on GABAA receptor subtypes. Their pharmacological relevance is increasingly being recognized. A new central nervous system (CNS) pharmacology is on the horizon.",

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