Selective GABAA circuits for novel CNS drugs

H. Möhler, U. Rudolph

Research output: Contribution to journalReview articlepeer-review


By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in brain function. GABAergic interneurons are highly diverse. The respective γ-aminobutyric acid (GABA)A receptor subtypes, therefore, provide new opportunities for targeting selective neuronal circuits. In addition, multiple sites for drug interactions are present on GABAA receptor subtypes. Their pharmacological relevance is increasingly being recognized. A new central nervous system (CNS) pharmacology is on the horizon.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalDrug Discovery Today: Therapeutic Strategies
Issue number1
StatePublished - Sep 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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