Selective feedback control of spastic musculature in a canine model

M. Broniatowski, K. Azar, C. R. Davies, G. B. Jacobs, H. M. Tucker

Research output: Contribution to journalArticlepeer-review

Abstract

Muscular spasm, the etiology of which remains elusive, has been difficult to control. The authors, therefore, proposed selective restraint of forced contractions by a closed-loop circuit. In four dogs, the strap (n = 6) and thyroarytenoid (n = 4) muscles were submitted to tetanic contractions via bipolar supramaximal stimulation (30 Hz, 6 mA, 0.5 msec) of ansa hypoglossi and recurrent laryngeal nerves, respectively. Subsequent reduction of distance between two sonomicrometer crystals embedded into muscle was used in lieu of 'spastic information' for a stimulator to deliver blocking signals through tripolar electrodes passed downstream. By modifying frequency (30-110 Hz) and current (60-95%) distribution between the central cathode and the peripheral anodes, significant relaxation (up to 100%) was recorded within 'blocking windows', varying with each nerve (3-18 mA sweeps). The selective restraint of unwanted contractions, leaving 'normal' subthreshold tone undisturbed, may offer a more mature approach to spastic disorders than destructive procedures, such as nerve section and its chemical counterpart, botulinum toxin injection.

Original languageEnglish (US)
Pages (from-to)M248-M252
JournalASAIO Journal
Volume38
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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