TY - JOUR
T1 - Seeking a Spotless Mind
T2 - Extinction, Deconsolidation, and Erasure of Fear Memory
AU - Maren, Stephen
PY - 2011/6/9
Y1 - 2011/6/9
N2 - Learning to contend with threats in the environment is essential to survival, but dysregulation of memories for traumatic events can lead to disabling psychopathology. Recent years have witnessed an impressive growth in our understanding of the neural systems and synaptic mechanisms underlying emotional memory formation. As a consequence, interest has emerged in developing strategies for suppressing, if not eliminating, fear memories. Here, I review recent work employing sophisticated behavioral, pharmacological, and molecular tools to target fear memories, placing these memories firmly behind the crosshairs of neurobiologically informed interventions.
AB - Learning to contend with threats in the environment is essential to survival, but dysregulation of memories for traumatic events can lead to disabling psychopathology. Recent years have witnessed an impressive growth in our understanding of the neural systems and synaptic mechanisms underlying emotional memory formation. As a consequence, interest has emerged in developing strategies for suppressing, if not eliminating, fear memories. Here, I review recent work employing sophisticated behavioral, pharmacological, and molecular tools to target fear memories, placing these memories firmly behind the crosshairs of neurobiologically informed interventions.
UR - http://www.scopus.com/inward/record.url?scp=79958055504&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958055504&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2011.04.023
DO - 10.1016/j.neuron.2011.04.023
M3 - Review article
C2 - 21658578
AN - SCOPUS:79958055504
SN - 0896-6273
VL - 70
SP - 830
EP - 845
JO - Neuron
JF - Neuron
IS - 5
ER -