TY - JOUR
T1 - Sedentary behavior and mortality in older women
T2 - The women's health initiative
AU - Seguin, Rebecca
AU - Buchner, David M.
AU - Liu, Jingmin
AU - Allison, Matthew
AU - Manini, Todd
AU - Wang, Ching Yun
AU - Manson, Joann E.
AU - Messina, Catherine R.
AU - Patel, Mahesh J.
AU - Moreland, Larry
AU - Stefanick, Marcia L.
AU - Lacroix, Andrea Z.
N1 - Funding Information:
The WHI program is funded by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, U.S. Department of Health and Human Services through Contracts N01WH22110, 24152, 32100-32102, 32105-32106, 32108-32109, 32111-32113, 32115, 32118-32119, 32122, 42107-42126, 42129-42132, and 44221 This work was also supported by PO1 CA53996, R01AG025441-03, and T32 AG027677.
Funding Information:
Dr. Seguin was supported by a grant from the National Heart, Lung, and Blood Institute (K01 HL108807). Dr. Buchner is supported in part as a Shahid and Ann Carlson Khan Professor of Applied Health Sciences, and by grants from the National Heart, Lung, and Blood Institute (5 R01 H205065-02) and from USDA NIFA (2011-27001-30101). Ms. Liu was supported by N01WH22110 sponsored by the National Heart, Lung, and Blood Institute. Dr. Manini is supported by the National Institute on Aging (R21AG031974) and by University of Florida Claude D. Pepper Center awarded by the National Institute on Aging (P30AG028740).
Funding Information:
Dr. Wang was supported by the National Cancer Institute (P01 CA53996) and the National Institute of Environmental Health Sciences (R01 ES017030). Dr. LaCroix was supported by 5R01AG025441-03 sponsored by the National Institute of Aging.
PY - 2014/2
Y1 - 2014/2
N2 - Background Although epidemiologic studies have shown associations between sedentary behavior and mortality, few have focused on older women with adequate minority representation and few have controlled for both physical activity and functional status. Purpose The objective of this study was to determine the relationship between sedentary time and total; cardiovascular disease (CVD); coronary heart disease (CHD); and cancer mortality in a prospective, multiethnic cohort of postmenopausal women. Methods The study population included 92,234 women aged 50-79 years at baseline (1993-1998) who participated in the Women's Health Initiative Observational Study through September 2010. Self-reported sedentary time was assessed by questionnaire and examined in 4 categories (≤4, >4-8, ≥8-11, >11 hours). Mortality risks were examined using Cox proportional hazard models adjusting for confounders. Models were also stratified by age, race/ethnicity, body mass index, physical activity, physical function, and chronic disease to examine possible effect modification. Analyses were conducted in 2012-2013. Results The mean follow-up period was 12 years. Compared with women who reported the least sedentary time, women reporting the highest sedentary time had increased risk of all-cause mortality in the multivariate model (HR=1.12, 95% CI=1.05, 1.21). Results comparing the highest versus lowest categories for CVD, CHD, and cancer mortality were as follows: HR=1.13, 95% CI=0.99, 1.29; HR=1.27, 95% CI=1.04, 1.55; and HR=1.21, 95% CI=1.07, 1.37, respectively. For all mortality outcomes, there were significant linear tests for trend. Conclusions There was a linear relationship between greater amounts of sedentary time and mortality risk after controlling for multiple potential confounders.
AB - Background Although epidemiologic studies have shown associations between sedentary behavior and mortality, few have focused on older women with adequate minority representation and few have controlled for both physical activity and functional status. Purpose The objective of this study was to determine the relationship between sedentary time and total; cardiovascular disease (CVD); coronary heart disease (CHD); and cancer mortality in a prospective, multiethnic cohort of postmenopausal women. Methods The study population included 92,234 women aged 50-79 years at baseline (1993-1998) who participated in the Women's Health Initiative Observational Study through September 2010. Self-reported sedentary time was assessed by questionnaire and examined in 4 categories (≤4, >4-8, ≥8-11, >11 hours). Mortality risks were examined using Cox proportional hazard models adjusting for confounders. Models were also stratified by age, race/ethnicity, body mass index, physical activity, physical function, and chronic disease to examine possible effect modification. Analyses were conducted in 2012-2013. Results The mean follow-up period was 12 years. Compared with women who reported the least sedentary time, women reporting the highest sedentary time had increased risk of all-cause mortality in the multivariate model (HR=1.12, 95% CI=1.05, 1.21). Results comparing the highest versus lowest categories for CVD, CHD, and cancer mortality were as follows: HR=1.13, 95% CI=0.99, 1.29; HR=1.27, 95% CI=1.04, 1.55; and HR=1.21, 95% CI=1.07, 1.37, respectively. For all mortality outcomes, there were significant linear tests for trend. Conclusions There was a linear relationship between greater amounts of sedentary time and mortality risk after controlling for multiple potential confounders.
UR - http://www.scopus.com/inward/record.url?scp=84892513969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892513969&partnerID=8YFLogxK
U2 - 10.1016/j.amepre.2013.10.021
DO - 10.1016/j.amepre.2013.10.021
M3 - Article
C2 - 24439345
AN - SCOPUS:84892513969
VL - 46
SP - 122
EP - 135
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
SN - 0749-3797
IS - 2
ER -