Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring

Alexandra L. Gerea; Katie M. Branscum; Jarrod B. King; Jianlan You; Douglas R. Powell; Andrew N. Miller; John R. Spear; Robert H. Cichewicz

doi:10.1016/j.tetlet.2012.05.156

Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring

Alexandra L. Gerea, Katie M. Branscum, Jarrod B. King, Jianlan You, Douglas R. Powell, Andrew N. Miller, John R. Spear, Robert H. Cichewicz

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Abstract

A collection of fungal isolates was obtained from a complex microbial mat, which occupied an iron-rich freshwater spring that feeds into Clear Creek, Golden, Colorado, USA. Two of the fungal isolates, a Glomeromycete (possibly Entrophospora sp.) and a Dothideomycete (possibly Phaeosphaeria sp.), were investigated for bioactive secondary metabolites. In total, six new compounds consisting of clearanols A-E (5, 6, 10-12) and disulochrin (7) were purified and their structures were determined. Disulochrin exhibited modest antibacterial activity against methicillin-resistant Staphylococcus aureus, whereas clearanol C showed weak inhibitory activity against Candida albicans biofilm formation.

Original language	English (US)
Pages (from-to)	4202-4205
Number of pages	4
Journal	Tetrahedron Letters
Volume	53
Issue number	32
DOIs	https://doi.org/10.1016/j.tetlet.2012.05.156
State	Published - Aug 8 2012

Keywords

Biofilm
Fungi
Microbial mat
Secondary metabolites

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2012.05.156

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title = "Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring",

abstract = "A collection of fungal isolates was obtained from a complex microbial mat, which occupied an iron-rich freshwater spring that feeds into Clear Creek, Golden, Colorado, USA. Two of the fungal isolates, a Glomeromycete (possibly Entrophospora sp.) and a Dothideomycete (possibly Phaeosphaeria sp.), were investigated for bioactive secondary metabolites. In total, six new compounds consisting of clearanols A-E (5, 6, 10-12) and disulochrin (7) were purified and their structures were determined. Disulochrin exhibited modest antibacterial activity against methicillin-resistant Staphylococcus aureus, whereas clearanol C showed weak inhibitory activity against Candida albicans biofilm formation.",

keywords = "Biofilm, Fungi, Microbial mat, Secondary metabolites",

author = "Gerea, {Alexandra L.} and Branscum, {Katie M.} and King, {Jarrod B.} and Jianlan You and Powell, {Douglas R.} and Miller, {Andrew N.} and Spear, {John R.} and Cichewicz, {Robert H.}",

note = "Financial support from the National Institutes of Health (1R01GM092219 and 1R01AI085161) is greatly appreciated. The X-ray diffractometer was purchased through a Grant from the National Science Foundation (CHE-0130835).",

year = "2012",

month = aug,

day = "8",

doi = "10.1016/j.tetlet.2012.05.156",

language = "English (US)",

volume = "53",

pages = "4202--4205",

journal = "Tetrahedron Letters",

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T1 - Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring

AU - Gerea, Alexandra L.

AU - Branscum, Katie M.

AU - King, Jarrod B.

AU - You, Jianlan

AU - Powell, Douglas R.

AU - Miller, Andrew N.

AU - Spear, John R.

AU - Cichewicz, Robert H.

N1 - Financial support from the National Institutes of Health (1R01GM092219 and 1R01AI085161) is greatly appreciated. The X-ray diffractometer was purchased through a Grant from the National Science Foundation (CHE-0130835).

PY - 2012/8/8

Y1 - 2012/8/8

N2 - A collection of fungal isolates was obtained from a complex microbial mat, which occupied an iron-rich freshwater spring that feeds into Clear Creek, Golden, Colorado, USA. Two of the fungal isolates, a Glomeromycete (possibly Entrophospora sp.) and a Dothideomycete (possibly Phaeosphaeria sp.), were investigated for bioactive secondary metabolites. In total, six new compounds consisting of clearanols A-E (5, 6, 10-12) and disulochrin (7) were purified and their structures were determined. Disulochrin exhibited modest antibacterial activity against methicillin-resistant Staphylococcus aureus, whereas clearanol C showed weak inhibitory activity against Candida albicans biofilm formation.

AB - A collection of fungal isolates was obtained from a complex microbial mat, which occupied an iron-rich freshwater spring that feeds into Clear Creek, Golden, Colorado, USA. Two of the fungal isolates, a Glomeromycete (possibly Entrophospora sp.) and a Dothideomycete (possibly Phaeosphaeria sp.), were investigated for bioactive secondary metabolites. In total, six new compounds consisting of clearanols A-E (5, 6, 10-12) and disulochrin (7) were purified and their structures were determined. Disulochrin exhibited modest antibacterial activity against methicillin-resistant Staphylococcus aureus, whereas clearanol C showed weak inhibitory activity against Candida albicans biofilm formation.

KW - Biofilm

KW - Fungi

KW - Microbial mat

KW - Secondary metabolites

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SN - 0040-4039

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 32

ER -

Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring

Abstract

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