@article{57dc246316a04cc7b7d198bd6cc53f6d,
title = "Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities",
abstract = "Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1-6, together with five known compounds, 7-11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structural scaffolds, and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.",
author = "Tran, {Trong D.} and Wilson, {Brice A.P.} and Henrich, {Curtis J.} and Staudt, {Louis M.} and Krumpe, {Lauren R.H.} and Smith, {Emily A.} and Jarrod King and Wendt, {Karen L.} and Stchigel, {Alberto M.} and Miller, {Andrew N.} and Cichewicz, {Robert H.} and O'Keefe, {Barry R.} and Gustafson, {Kirk R.}",
note = "†Molecular Targets Program, Center of Cancer Research, National Cancer Institute, Frederick, Maryland 21701-1201, United States ‡Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland 21702-1201, United States §Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, United States ⊥Natural Products Discovery Group, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019-5251, United States ∥Mycology Unit, Universitat Rovira i Virgili, C/Sant Lloren{\c c} 21, 43201 Reus, Spain #Illinois Natural History Survey, University of Illinois, 1816 South Oak Street, Champaign, Illinois 61820-6970, United States □Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21701-1201, United States Grateful acknowledgement goes to A. Wamiru for MALT1 assay support and H. Bokesch for assistance with HRMS studies. This research utilized the computational resources of the NIH HPC Biowulf cluster, and it was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, and with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001E. The research was also supported in part by a grant from the National Cancer Institute (UO1CA182740). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.",
year = "2019",
month = jan,
day = "25",
doi = "10.1021/acs.jnatprod.8b00871",
language = "English (US)",
volume = "82",
pages = "154--162",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "1",
}