Secondary ion mass spectrometry and Raman spectroscopy for tissue engineering applications

Yelena Ilin; Mary L. Kraft

doi:10.1016/j.copbio.2014.10.011

Secondary ion mass spectrometry and Raman spectroscopy for tissue engineering applications

Research output: Contribution to journal › Review article › peer-review

Abstract

Identifying the matrix properties that permit directing stem cell fate is crucial for expanding desired cell lineages ex vivo for disease treatment. Such efforts require knowledge of matrix surface chemistry and the cell responses they elicit. Recent progress in analyzing biomaterial composition and identifying cell phenotype with two label-free chemical imaging techniques, TOF-SIMS and Raman spectroscopy are presented. TOF-SIMS is becoming indispensable for the surface characterization of biomaterial scaffolds. Developments in TOF-SIMS data analysis enable correlating surface chemistry with biological response. Advances in the interpretation of Raman spectra permit identifying the fate decisions of individual, living cells with location specificity. Here we highlight this progress and discuss further improvements that would facilitate efforts to develop artificial scaffolds for tissue regeneration.

Original language	English (US)
Pages (from-to)	108-116
Number of pages	9
Journal	Current Opinion in Biotechnology
Volume	31
DOIs	https://doi.org/10.1016/j.copbio.2014.10.011
State	Published - Feb 1 2015

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/j.copbio.2014.10.011

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title = "Secondary ion mass spectrometry and Raman spectroscopy for tissue engineering applications",

abstract = "Identifying the matrix properties that permit directing stem cell fate is crucial for expanding desired cell lineages ex vivo for disease treatment. Such efforts require knowledge of matrix surface chemistry and the cell responses they elicit. Recent progress in analyzing biomaterial composition and identifying cell phenotype with two label-free chemical imaging techniques, TOF-SIMS and Raman spectroscopy are presented. TOF-SIMS is becoming indispensable for the surface characterization of biomaterial scaffolds. Developments in TOF-SIMS data analysis enable correlating surface chemistry with biological response. Advances in the interpretation of Raman spectra permit identifying the fate decisions of individual, living cells with location specificity. Here we highlight this progress and discuss further improvements that would facilitate efforts to develop artificial scaffolds for tissue regeneration.",

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note = "Funding Information: This work was partially supported by the NIH Training Program in the Chemistry-Biology Interface T32 GM070421, and a grant from the U.S. National Science Foundation ( CHE-1058809 ). Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd.",

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AU - Kraft, Mary L.

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AB - Identifying the matrix properties that permit directing stem cell fate is crucial for expanding desired cell lineages ex vivo for disease treatment. Such efforts require knowledge of matrix surface chemistry and the cell responses they elicit. Recent progress in analyzing biomaterial composition and identifying cell phenotype with two label-free chemical imaging techniques, TOF-SIMS and Raman spectroscopy are presented. TOF-SIMS is becoming indispensable for the surface characterization of biomaterial scaffolds. Developments in TOF-SIMS data analysis enable correlating surface chemistry with biological response. Advances in the interpretation of Raman spectra permit identifying the fate decisions of individual, living cells with location specificity. Here we highlight this progress and discuss further improvements that would facilitate efforts to develop artificial scaffolds for tissue regeneration.

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Secondary ion mass spectrometry and Raman spectroscopy for tissue engineering applications

Abstract

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