Screening of optically active nickel initiators for enantioasymmetric polymerization of γ-benzyl glutamate-N-carboxyanhydride

Jianjun Cheng, Timothy J. Deming

Research output: Contribution to journalArticlepeer-review

Abstract

The polymerization of a-amino acid-N-carboxyanhydrides (NCAs) to form block copolypeptides was explored for applications as biomedical materials. To promote structural development and biological activity with the use of synthetic, racemic amino acids, the use of optically active initiators to develop enantioasymmetric polymerizations was pursued. In particular, with the use of chiral pyridinyl exazoline ligands in nickel initiators, γ-benzyl-glutamate NCA was enantioasymmetrically polymerized.

Original languageEnglish (US)
Pages (from-to)4745-4747
Number of pages3
JournalMacromolecules
Volume32
Issue number14
DOIs
StatePublished - Jul 13 1999
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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