Scope and limitations of a rapid radiobromination technique

Karen D. McElvany, Michael J. Welch, John A. Katzenellenbogen, Stephen G. Senderoff, Glenn E. Bentley, Patrick M. Grant

Research output: Contribution to journalArticlepeer-review

Abstract

A series of model compounds has been labeled with bromine-77 using a recently described method for rapid radiobromination. Characterization of the 77Br-labeled products has shown the technique to be unsuitable for labeling fragile molecules, such as proteins. Thus, the technique should not be considered a generally applicable radiobromination method; however, it may be a useful means of attaching radiobromine to some simple molecules which are not sensitive to oxidative conditions and do not possess multiple sites for halogenation.

Original languageEnglish (US)
Pages (from-to)411-416
Number of pages6
JournalTopics in Catalysis
Volume32
Issue number6
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Radiation
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging

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