Schizophrenia polygenic risk score in psychosis proneness

Patricia Mas-Bermejo, Sergi Papiol, Marc Via, Paula Rovira, Pilar Torrecilla, Thomas R. Kwapil, Neus Barrantes-Vidal, Araceli Rosa

Research output: Contribution to journalArticlepeer-review


Schizophrenia (SZ) is a complex disorder with a highly polygenic inheritance. It can be conceived as the extreme expression of a continuum of traits that are present in the general population often broadly referred to as schizotypy. However, it is still poorly understood how these traits overlap genetically with the disorder. We investigated whether polygenic risk for SZ is associated with these disorder-related phenotypes (schizotypy, psychotic-like experiences, and subclinical psychopathology) in a sample of 253 non-clinically identified participants. Polygenic risk scores (PRSs) were constructed based on the latest SZ genome-wide association study using the PRS-CS method. Their association with self-report and interview measures of SZ-related traits was tested. No association with either schizotypy or psychotic-like experiences was found. However, we identified a significant association with the Motor Change subscale of the Comprehensive Assessment of At-Risk Mental States (CAARMS) interview. Our results indicate that the genetic overlap of SZ with schizotypy and psychotic-like experiences is less robust than previously hypothesized. The relationship between high PRS for SZ and motor abnormalities could reflect neurodevelopmental processes associated with psychosis proneness and SZ.

Original languageEnglish (US)
Pages (from-to)1665-1675
Number of pages11
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Issue number8
StatePublished - Dec 2023


  • Genetic overlap
  • Motor abnormalities
  • Polygenic risk score
  • Psychotic-like experiences
  • Schizophrenia
  • Schizotypy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Biological Psychiatry


Dive into the research topics of 'Schizophrenia polygenic risk score in psychosis proneness'. Together they form a unique fingerprint.

Cite this