Scalable synthesis of reduced toxicity derivative of amphotericin B

Martin D. Burke; Brice E. Uno; Souvik Rakshit

Scalable synthesis of reduced toxicity derivative of amphotericin B

Martin D. Burke (Inventor)
, Brice E. Uno (Inventor)
, Souvik Rakshit (Inventor)

Research output: Patent

Abstract

Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.

Original language	English (US)
U.S. patent number	10683318
Filing date	10/1/18
State	Published - Jun 16 2020

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title = "Scalable synthesis of reduced toxicity derivative of amphotericin B",

abstract = "Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.",

author = "Burke, \{Martin D.\} and Uno, \{Brice E.\} and Souvik Rakshit",

note = "GOVERNMENT SUPPORT This invention was made with government support under Grant No. GM080436, awarded by the National Institutes of Health. The government has certain rights in the invention.; 10683318",

year = "2020",

month = jun,

day = "16",

language = "English (US)",

type = "Patent",

}

TY - PAT

T1 - Scalable synthesis of reduced toxicity derivative of amphotericin B

AU - Burke, Martin D.

AU - Uno, Brice E.

AU - Rakshit, Souvik

N1 - GOVERNMENT SUPPORT This invention was made with government support under Grant No. GM080436, awarded by the National Institutes of Health. The government has certain rights in the invention.

PY - 2020/6/16

Y1 - 2020/6/16

N2 - Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.

AB - Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.

M3 - Patent

M1 - 10683318

Y2 - 2018/10/01

ER -

Scalable synthesis of reduced toxicity derivative of amphotericin B

Abstract

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