Scalable synthesis of reduced toxicity derivative of amphotericin B

Martin D Burke; Brice E Uno; Souvik Rakshit

Scalable synthesis of reduced toxicity derivative of amphotericin B

Martin D Burke (Inventor), Brice E Uno (Inventor), Souvik Rakshit (Inventor)

Research output: Patent

Abstract

Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.

Original language	English (US)
U.S. patent number	10087206
Filing date	10/16/15
State	Published - Oct 2 2018

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title = "Scalable synthesis of reduced toxicity derivative of amphotericin B",

abstract = "Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.",

author = "Burke, {Martin D} and Uno, {Brice E} and Souvik Rakshit",

note = "GOVERNMENT SUPPORT This invention was made with government support under Grant No. GM080436, awarded by the National Institutes of Health. The government has certain rights in the invention.; 10087206",

year = "2018",

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day = "2",

language = "English (US)",

type = "Patent",

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TY - PAT

T1 - Scalable synthesis of reduced toxicity derivative of amphotericin B

AU - Burke, Martin D

AU - Uno, Brice E

AU - Rakshit, Souvik

N1 - GOVERNMENT SUPPORT This invention was made with government support under Grant No. GM080436, awarded by the National Institutes of Health. The government has certain rights in the invention.

PY - 2018/10/2

Y1 - 2018/10/2

N2 - Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.

AB - Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.

M3 - Patent

M1 - 10087206

Y2 - 2015/10/16

ER -

Scalable synthesis of reduced toxicity derivative of amphotericin B

Abstract

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