Protein engineering studies show that conformations in the folding transition state ensemble can be structurally polarized. In two SH3 β-sheet domains, the formation of hydrophobic contacts goes hand in hand with the formation of the solvated distal loop β-turn, while large parts of the molecule remain unstructured in the ensemble.
|Original language||English (US)|
|Number of pages||4|
|Journal||Nature Structural and Molecular Biology|
|State||Published - Aug 1998|
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology