Sarcomere assembly in C. elegans muscle.

Donald G. Moerman, Benjamin D. Williams

Research output: Contribution to journalReview article

Abstract

Sarcomeres within body wall muscle in C. elegans include attachments to the sarcolemma that are remarkably similar in structure to vertebrate adhesion complexes. Crucial early steps in muscle sarcomere assembly, a highly orchestrated affair involving many proteins, involve the assembly of these sarcomere attachments. The steps involved in initiating the correct placement of these attachments and other sarcomere substructures are poorly understood. Using mutants in C. elegans we are attempting to dissect the various steps in this process. We review what has been discovered to date and present a model of sarcomere assembly that initiates at the plasma membrane and involves proteins within muscle, the hypodermis and within the extracellular matrix.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalWormBook : the online review of C. elegans biology
DOIs
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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