SANGUINARINE, A PHOTOTOXIC H2O2‐PRODUCING ALKALOID

R. W. Tuveson, Richard A. Larson, Karen A. Marley, Gui‐rong ‐r Wang, May R. Berenbaum

Research output: Contribution to journalArticle

Abstract

Abstract— Sanguinarine chloride, a quaternary salt of a benzophenanthrene alkaloid, was phototoxic to catalase‐deficient strains of Escherichia coli but not to Trichoplusia ni (cabbage looper moth larvae), an insect with high levels of catalase activity. Chemical analyses confirm that sanguinarine is an efficient producer of H2O2. This differential toxicity suggests that the mode of phototoxic action involves production of H2O2 which could be detoxified in many organisms by catalase.

Original languageEnglish (US)
Pages (from-to)733-738
Number of pages6
JournalPhotochemistry and Photobiology
Volume50
Issue number6
DOIs
StatePublished - Dec 1989

Fingerprint

catalase
alkaloids
Alkaloids
Catalase
moths
larvae
insects
Moths
Brassica
Escherichia
organisms
toxicity
Escherichia coli
Larva
Toxicity
Insects
Salts
chlorides
salts
sanguinarine

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

Cite this

SANGUINARINE, A PHOTOTOXIC H2O2‐PRODUCING ALKALOID. / Tuveson, R. W.; Larson, Richard A.; Marley, Karen A.; Wang, Gui‐rong ‐r; Berenbaum, May R.

In: Photochemistry and Photobiology, Vol. 50, No. 6, 12.1989, p. 733-738.

Research output: Contribution to journalArticle

Tuveson, R. W. ; Larson, Richard A. ; Marley, Karen A. ; Wang, Gui‐rong ‐r ; Berenbaum, May R. / SANGUINARINE, A PHOTOTOXIC H2O2‐PRODUCING ALKALOID. In: Photochemistry and Photobiology. 1989 ; Vol. 50, No. 6. pp. 733-738.
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