SANGUINARINE, A PHOTOTOXIC H2O2‐PRODUCING ALKALOID

R. W. Tuveson, Richard A. Larson, Karen A. Marley, Gui‐rong ‐r Wang, May R. Berenbaum

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract— Sanguinarine chloride, a quaternary salt of a benzophenanthrene alkaloid, was phototoxic to catalase‐deficient strains of Escherichia coli but not to Trichoplusia ni (cabbage looper moth larvae), an insect with high levels of catalase activity. Chemical analyses confirm that sanguinarine is an efficient producer of H2O2. This differential toxicity suggests that the mode of phototoxic action involves production of H2O2 which could be detoxified in many organisms by catalase.

Original languageEnglish (US)
Pages (from-to)733-738
Number of pages6
JournalPhotochemistry and Photobiology
Volume50
Issue number6
DOIs
StatePublished - Dec 1989

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

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