Salmonella as a biological "Trojan horse" for neoplasia: Future possibilities including brain cancer

Gregory S.A. Mlynarczyk, Carrie A. Berg, Isabelle C. Withrock, Meghan E. Fick, Stephen J. Anderson, Lauren A. Laboissonniere, Matthew A. Jefferson, Matthew T. Brewer, Matthew L. Stock, Jennifer K. Lange, K. C. Luna, Sreemoyee Acharya, Sriharsha Kanuri, Shaunik Sharma, Naveen C. Kondru, Garrett R. McCormack, Steve A. Carlson

Research output: Contribution to journalArticlepeer-review

Abstract

This manuscript considers available evidence that a specific Salmonella strain could be used as an effective orally-administered option for cancer therapy involving the brain. It has been established that Salmonella preferentially colonizes neoplastic tissue and thrives as a facultative anaerobe in the intra-tumor environment. Although Salmonella accumulates in tumors by passive processes, it is still possible for lipopolysaccharide to cause sepsis and endotoxic shock during the migration of bacteria to the tumor site. An LPS-free version of a recently identified Salmonella isolate may have the capability to circumvent the blood brain barrier and provide a safer method of reaching brain tumors. This isolate merits further research as a "Trojan horse" for future oral biotherapy of brain cancer.

Original languageEnglish (US)
Pages (from-to)343-345
Number of pages3
JournalMedical Hypotheses
Volume83
Issue number3
DOIs
StatePublished - Sep 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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