Safety of pulsed high intensity focused ultrasound for enhanced drug and gene delivery

Anthony W. Kam, Honghui Wang, Keyvan Farahani, David Thomasson, Brian O'Neill, Mary Angstadt, Johnny Jesson, King C.P. Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

For a limited range of exposure parameters, pulsed high intensity focused ultrasound (HIFU) has been shown to increase the delivery of certain systemically administered macromolecular diagnostic and therapeutic agents in mice. The mechanism for the enhanced delivery has not been demonstrated definitively and, in principle, can include thermal, cavitational, and non-cavitation mechanical effects. The sonicated tissue has no damage on histology. As a step towards clinical translation, the safety of this technique needs to be assessed in a clinically relevant manner. In this study, the safety of pulsed HIFU is evaluated with near real-time phase shift magnetic resonance (MR) thermometry and anatomic MR imaging using rabbits as subjects. MR guidance enables pulsed HIFU enhanced delivery to be implemented safely from a thermal standpoint. Although the effects of pulsed HIFU are not seen on anatomic MR images, they may be detected on MR sequences sensitive to permeability, diffusion, and elasticity. Such work that may optimize pulsed HIFU enhanced delivery is in progress.

Original languageEnglish (US)
Title of host publication6th International Symposium on Therapeutic Ultrasound
Pages455-461
Number of pages7
DOIs
StatePublished - Sep 24 2007
Externally publishedYes
Event6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND - Oxford, United Kingdom
Duration: Aug 30 2007Sep 2 2007

Publication series

NameAIP Conference Proceedings
Volume911
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND
CountryUnited Kingdom
CityOxford
Period8/30/079/2/07

Keywords

  • Drug and gene delivery
  • MR thermometry
  • Pulsed high intensity focused ultrasound
  • Safety

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Kam, A. W., Wang, H., Farahani, K., Thomasson, D., O'Neill, B., Angstadt, M., Jesson, J., & Li, K. C. P. (2007). Safety of pulsed high intensity focused ultrasound for enhanced drug and gene delivery. In 6th International Symposium on Therapeutic Ultrasound (pp. 455-461). (AIP Conference Proceedings; Vol. 911). https://doi.org/10.1063/1.2744313