S-100 proteins in the human peripheral nervous system.

T. Gonzalez-Martinez, P. Perez-Piñera, B. Díaz-Esnal, J. A. Vega

Research output: Contribution to journalReview articlepeer-review


This article reviews the distribution of S100 proteins in the human peripheral nervous system. The expression of S100 by peripheral glial cells seems to be a distinctive fact of these cells, independently of their localization and their ability to myelinate or not. S100 proteins expressing cells include satellite cells of sensory, sympathetic and enteric ganglia, supporting cells of the adrenal medulla, myelinating and non-myelinating Schwann cells in the nerve trunks, and the Schwann-related cells of sensory corpuscles. In addition, S100 proteins are expressed in peripheral neurons. Most of them express S100alpha protein, and a subpopulation of sensory neurons in dorsal root ganglia contains S100beta protein or S100alpha plus S100beta proteins.

Original languageEnglish (US)
Pages (from-to)633-638
Number of pages6
JournalMicroscopy research and technique
Issue number6
StatePublished - Apr 15 2003
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology


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