RUNX3 Meets the Ubiquitin-Proteasome System in Cancer

Albano Toska, Nikita Modi, Lin-Feng Chen

Research output: Contribution to journalReview articlepeer-review


RUNX3 is a transcription factor with regulatory roles in cell proliferation and development. While largely characterized as a tumor suppressor, RUNX3 can also be oncogenic in certain cancers. Many factors account for the tumor suppressor function of RUNX3, which is reflected by its ability to suppress cancer cell proliferation after expression-restoration, and its inactivation in cancer cells. Ubiquitination and proteasomal degradation represent a major mechanism for the inactivation of RUNX3 and the suppression of cancer cell proliferation. On the one hand, RUNX3 has been shown to facilitate the ubiquitination and proteasomal degradation of oncogenic proteins. On the other hand, RUNX3 can be inactivated through the ubiquitin–proteasome system. This review encapsulates two facets of RUNX3 in cancer: how RUNX3 suppresses cell proliferation by facilitating the ubiquitination and proteasomal degradation of oncogenic proteins, and how RUNX3 is degraded itself through interacting RNA-, protein-, and pathogen-mediated ubiquitination and proteasomal degradation.
Original languageEnglish (US)
Article number717
Issue number5
StatePublished - Mar 2023


  • E3 ligase
  • proteasomal degradation
  • RUNX3
  • tumor suppressor
  • ubiquitination

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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