R∗2 mapping for robust brain function detection in the presence of magnetic field inhomogeneity

Giang Chau Ngo, Bradley P. Sutton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

T∗2 mapping or R∗2 mapping for brain function offers advantages such as providing quantitative measurements independent of the MRI acquisition parameters (e.g. echo time TE). However, magnetic field susceptibility in the human brain can prevent an accurate estimation of R∗2, which in turn impacts the ability to study brain function. The present work investigates the effects of in-plane magnetic susceptibility-induced magnetic field gradients on R∗2 decay. An iterative method is developed for R∗2 estimation with an increased robustness to field inhomogeneity. The new method is further tested in a visual fMRI experiment with and without magnetic field gradients and its performance is compared to a standard BOLD fMRI and a BOLD fMRI based on echo summation. Reduced sensitivity in fMRI to in-plane magnetic gradients is obtained with the present methodology.

Original languageEnglish (US)
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1537-1540
Number of pages4
ISBN (Electronic)9781424479290
DOIs
StatePublished - Nov 2 2014
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
Duration: Aug 26 2014Aug 30 2014

Publication series

Name2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Other

Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Country/TerritoryUnited States
CityChicago
Period8/26/148/30/14

ASJC Scopus subject areas

  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering
  • General Medicine

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