RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media

Mark Palmeri; Kathy Nightingale; Shana Fielding; Ned Rouze; Yufeng Deng; Ted Lynch; Shigao Chen; Pengfei Song; Matthew Urban; Hua Xie; Keith Wear; Brian Garra; Andy Milkowski; Stephen Rosenzweig; Paul Carson; Richard Barr; Vijay Shamdasani; Michael MacDonald; Michael Wang; Gilles Guenette; Yasuo Miyajima; Yoko Okamura; Manish Dhyani; Anthony Samir; Zaegyoo Hah; Glen McLaughlin; Albert Gee; Yuling Chen; David Napolitano; Steve McAleavey; Nancy Obuchowski; Timothy Hall

doi:10.1109/ULTSYM.2015.0283

RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media

Mark Palmeri, Kathy Nightingale, Shana Fielding, Ned Rouze, Yufeng Deng, Ted Lynch, Shigao Chen, Pengfei Song, Matthew Urban, Hua Xie, Keith Wear, Brian Garra, Andy Milkowski, Stephen Rosenzweig, Paul Carson, Richard Barr, Vijay Shamdasani, Michael MacDonald, Michael Wang, Gilles GuenetteYasuo Miyajima, Yoko Okamura, Manish Dhyani, Anthony Samir, Zaegyoo Hah, Glen McLaughlin, Albert Gee, Yuling Chen, David Napolitano, Steve McAleavey, Nancy Obuchowski, Timothy Hall

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Using ultrasonic shear wave speed (SWS) estimates has become popular to noninvasively evaluate liver fibrosis, but significant inter-system variability in liver SWS measurements can preclude meaningful comparison of measurements performed with different systems. The RSNA Quantitative Imaging Biomarker Alliance (QIBA) ultrasound SWS committee has been developing elastic and viscoelastic (VE) phantoms to evaluate system dependencies of SWS estimates. The objective of this study is to compare SWS measurements between commercially-available systems using phantoms that have viscoelastic properties similar to those observed in normal and fibrotic liver. CIRS, Inc. fabricated three phantoms using a proprietary oil-water emulsion infused in a Zerdine^® hydrogel that were matched in viscoelastic behavior to healthy and fibrotic human liver data. Phantoms were measured at academic, clinical, government and vendor sites using different systems with curvilinear arrays at multiple focal depths (3.0, 4.5 & 7.0 cm). The results of this study show that current-generation ultrasound SWS measurement systems are able to differentiate viscoelastic materials that span healthy to fibrotic liver. The deepest focal depth (7.0 cm) yielded the greatest inter-system variability for each phantom (maximum of 17.7%) as evaluated by IQR. Inter-system variability was consistent across all 3 phantoms and was not a function of stiffness. Median SWS estimates for the greatest outlier system for each phantom/focal depth combination ranged from 12.7-17.6%. Future efforts will include performing more robust statistical analyses of these data, comparing these phantom data trends with viscoelastic digital phantom data, providing vendors with study site data to refine their systems to have more consistent measurements, and integrating these data into the QIBA ultrasound shear wave speed measurement profile.

Original language	English (US)
Title of host publication	2015 IEEE International Ultrasonics Symposium, IUS 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479981823
DOIs	https://doi.org/10.1109/ULTSYM.2015.0283
State	Published - Nov 13 2015
Externally published	Yes
Event	IEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China Duration: Oct 21 2015 → Oct 24 2015

Publication series

Name	2015 IEEE International Ultrasonics Symposium, IUS 2015

Other

Other	IEEE International Ultrasonics Symposium, IUS 2015
Country/Territory	Taiwan, Province of China
City	Taipei
Period	10/21/15 → 10/24/15

ASJC Scopus subject areas

Acoustics and Ultrasonics

Online availability

10.1109/ULTSYM.2015.0283

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Palmeri, M., Nightingale, K., Fielding, S., Rouze, N., Deng, Y., Lynch, T., Chen, S., Song, P., Urban, M., Xie, H., Wear, K., Garra, B., Milkowski, A., Rosenzweig, S., Carson, P., Barr, R., Shamdasani, V., MacDonald, M., Wang, M., ... Hall, T. (2015). RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media. In 2015 IEEE International Ultrasonics Symposium, IUS 2015 [7329478] (2015 IEEE International Ultrasonics Symposium, IUS 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ULTSYM.2015.0283

RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media. / Palmeri, Mark; Nightingale, Kathy; Fielding, Shana et al.
2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7329478 (2015 IEEE International Ultrasonics Symposium, IUS 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Palmeri, M, Nightingale, K, Fielding, S, Rouze, N, Deng, Y, Lynch, T, Chen, S, Song, P, Urban, M, Xie, H, Wear, K, Garra, B, Milkowski, A, Rosenzweig, S, Carson, P, Barr, R, Shamdasani, V, MacDonald, M, Wang, M, Guenette, G, Miyajima, Y, Okamura, Y, Dhyani, M, Samir, A, Hah, Z, McLaughlin, G, Gee, A, Chen, Y, Napolitano, D, McAleavey, S, Obuchowski, N & Hall, T 2015, RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media. in 2015 IEEE International Ultrasonics Symposium, IUS 2015., 7329478, 2015 IEEE International Ultrasonics Symposium, IUS 2015, Institute of Electrical and Electronics Engineers Inc., IEEE International Ultrasonics Symposium, IUS 2015, Taipei, Taiwan, Province of China, 10/21/15. https://doi.org/10.1109/ULTSYM.2015.0283

Palmeri M, Nightingale K, Fielding S, Rouze N, Deng Y, Lynch T et al. RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media. In 2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers Inc. 2015. 7329478. (2015 IEEE International Ultrasonics Symposium, IUS 2015). doi: 10.1109/ULTSYM.2015.0283

@inproceedings{595c5c92ad174e6d867f8215dc110b2a,

title = "RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media",

abstract = "Using ultrasonic shear wave speed (SWS) estimates has become popular to noninvasively evaluate liver fibrosis, but significant inter-system variability in liver SWS measurements can preclude meaningful comparison of measurements performed with different systems. The RSNA Quantitative Imaging Biomarker Alliance (QIBA) ultrasound SWS committee has been developing elastic and viscoelastic (VE) phantoms to evaluate system dependencies of SWS estimates. The objective of this study is to compare SWS measurements between commercially-available systems using phantoms that have viscoelastic properties similar to those observed in normal and fibrotic liver. CIRS, Inc. fabricated three phantoms using a proprietary oil-water emulsion infused in a Zerdine{\textregistered} hydrogel that were matched in viscoelastic behavior to healthy and fibrotic human liver data. Phantoms were measured at academic, clinical, government and vendor sites using different systems with curvilinear arrays at multiple focal depths (3.0, 4.5 & 7.0 cm). The results of this study show that current-generation ultrasound SWS measurement systems are able to differentiate viscoelastic materials that span healthy to fibrotic liver. The deepest focal depth (7.0 cm) yielded the greatest inter-system variability for each phantom (maximum of 17.7%) as evaluated by IQR. Inter-system variability was consistent across all 3 phantoms and was not a function of stiffness. Median SWS estimates for the greatest outlier system for each phantom/focal depth combination ranged from 12.7-17.6%. Future efforts will include performing more robust statistical analyses of these data, comparing these phantom data trends with viscoelastic digital phantom data, providing vendors with study site data to refine their systems to have more consistent measurements, and integrating these data into the QIBA ultrasound shear wave speed measurement profile.",

author = "Mark Palmeri and Kathy Nightingale and Shana Fielding and Ned Rouze and Yufeng Deng and Ted Lynch and Shigao Chen and Pengfei Song and Matthew Urban and Hua Xie and Keith Wear and Brian Garra and Andy Milkowski and Stephen Rosenzweig and Paul Carson and Richard Barr and Vijay Shamdasani and Michael MacDonald and Michael Wang and Gilles Guenette and Yasuo Miyajima and Yoko Okamura and Manish Dhyani and Anthony Samir and Zaegyoo Hah and Glen McLaughlin and Albert Gee and Yuling Chen and David Napolitano and Steve McAleavey and Nancy Obuchowski and Timothy Hall",

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doi = "10.1109/ULTSYM.2015.0283",

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AU - Palmeri, Mark

AU - Nightingale, Kathy

AU - Fielding, Shana

AU - Rouze, Ned

AU - Deng, Yufeng

AU - Lynch, Ted

AU - Chen, Shigao

AU - Song, Pengfei

AU - Urban, Matthew

AU - Xie, Hua

AU - Wear, Keith

AU - Garra, Brian

AU - Milkowski, Andy

AU - Rosenzweig, Stephen

AU - Carson, Paul

AU - Barr, Richard

AU - Shamdasani, Vijay

AU - MacDonald, Michael

AU - Wang, Michael

AU - Guenette, Gilles

AU - Miyajima, Yasuo

AU - Okamura, Yoko

AU - Dhyani, Manish

AU - Samir, Anthony

AU - Hah, Zaegyoo

AU - McLaughlin, Glen

AU - Gee, Albert

AU - Chen, Yuling

AU - Napolitano, David

AU - McAleavey, Steve

AU - Obuchowski, Nancy

AU - Hall, Timothy

PY - 2015/11/13

Y1 - 2015/11/13

N2 - Using ultrasonic shear wave speed (SWS) estimates has become popular to noninvasively evaluate liver fibrosis, but significant inter-system variability in liver SWS measurements can preclude meaningful comparison of measurements performed with different systems. The RSNA Quantitative Imaging Biomarker Alliance (QIBA) ultrasound SWS committee has been developing elastic and viscoelastic (VE) phantoms to evaluate system dependencies of SWS estimates. The objective of this study is to compare SWS measurements between commercially-available systems using phantoms that have viscoelastic properties similar to those observed in normal and fibrotic liver. CIRS, Inc. fabricated three phantoms using a proprietary oil-water emulsion infused in a Zerdine® hydrogel that were matched in viscoelastic behavior to healthy and fibrotic human liver data. Phantoms were measured at academic, clinical, government and vendor sites using different systems with curvilinear arrays at multiple focal depths (3.0, 4.5 & 7.0 cm). The results of this study show that current-generation ultrasound SWS measurement systems are able to differentiate viscoelastic materials that span healthy to fibrotic liver. The deepest focal depth (7.0 cm) yielded the greatest inter-system variability for each phantom (maximum of 17.7%) as evaluated by IQR. Inter-system variability was consistent across all 3 phantoms and was not a function of stiffness. Median SWS estimates for the greatest outlier system for each phantom/focal depth combination ranged from 12.7-17.6%. Future efforts will include performing more robust statistical analyses of these data, comparing these phantom data trends with viscoelastic digital phantom data, providing vendors with study site data to refine their systems to have more consistent measurements, and integrating these data into the QIBA ultrasound shear wave speed measurement profile.

AB - Using ultrasonic shear wave speed (SWS) estimates has become popular to noninvasively evaluate liver fibrosis, but significant inter-system variability in liver SWS measurements can preclude meaningful comparison of measurements performed with different systems. The RSNA Quantitative Imaging Biomarker Alliance (QIBA) ultrasound SWS committee has been developing elastic and viscoelastic (VE) phantoms to evaluate system dependencies of SWS estimates. The objective of this study is to compare SWS measurements between commercially-available systems using phantoms that have viscoelastic properties similar to those observed in normal and fibrotic liver. CIRS, Inc. fabricated three phantoms using a proprietary oil-water emulsion infused in a Zerdine® hydrogel that were matched in viscoelastic behavior to healthy and fibrotic human liver data. Phantoms were measured at academic, clinical, government and vendor sites using different systems with curvilinear arrays at multiple focal depths (3.0, 4.5 & 7.0 cm). The results of this study show that current-generation ultrasound SWS measurement systems are able to differentiate viscoelastic materials that span healthy to fibrotic liver. The deepest focal depth (7.0 cm) yielded the greatest inter-system variability for each phantom (maximum of 17.7%) as evaluated by IQR. Inter-system variability was consistent across all 3 phantoms and was not a function of stiffness. Median SWS estimates for the greatest outlier system for each phantom/focal depth combination ranged from 12.7-17.6%. Future efforts will include performing more robust statistical analyses of these data, comparing these phantom data trends with viscoelastic digital phantom data, providing vendors with study site data to refine their systems to have more consistent measurements, and integrating these data into the QIBA ultrasound shear wave speed measurement profile.

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PB - Institute of Electrical and Electronics Engineers Inc.

T2 - IEEE International Ultrasonics Symposium, IUS 2015

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ER -

RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media

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