Roles for LBP and soluble CD14 in cellular uptake of LPS.

R. I. Tapping, J. A. Gegner, V. V. Kravchenko, P. S. Tobias

Research output: Contribution to journalReview articlepeer-review

Abstract

Roles for LBP and CD14 in the LPS dependent activation of a wide variety of cells have been established. In the work described here, we describe roles for these proteins in the binding and uptake of LPS by cells which express membrane CD14 and those which do not. Surprisingly, cell activation and LPS uptake appear to be independent phenomena with different protein requirements.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalProgress in clinical and biological research
Volume397
StatePublished - 1998

ASJC Scopus subject areas

  • Medicine(all)

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