Role of the T cell receptor α chain in stabilizing TCR-superantigen- MHC class II complexes

Peter S. Andersen, Pascal M. Lavoie, Rafick Pierre Sékaly, Hywyn Churchill, David M. Kranz, Patrick M. Schlievert, Klaus Karjalainen, Roy A. Mariuzza

Research output: Contribution to journalArticlepeer-review

Abstract

Superantigens (SAGs) activate T cells by simultaneously binding the Vβ domain of the TCR and MHC class II molecules on antigen-presenting cells. The preferential expression of certain Vα regions among SAG-reactive T cells has suggested that the TCR α chain may modulate the level of activation through an interaction with MHC. We demonstrate that the TCR α chain is required for maximum stabilization of the TCR-SAG-MHC complex and that the α chain increases the half-life of the complex to match those of TCR-peptide/MHC complexes. The site on the TCR α chain responsible for these effects is CDR2. Thus, the overall stability of the TCR-SAG-MHC complex is determined by the combination of three distinct interactions: TCR-SAG, SAG-MHC, and MHC- TCR.

Original languageEnglish (US)
Pages (from-to)473-483
Number of pages11
JournalImmunity
Volume10
Issue number4
DOIs
StatePublished - Apr 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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