Abstract

Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.

Original languageEnglish (US)
Pages (from-to)2467-2472
Number of pages6
JournalLife Sciences
Volume68
Issue number22-23
DOIs
StatePublished - Apr 27 2001

Keywords

  • Acetylcholine
  • cGMP/PKG signaling
  • Circadian rhythms
  • Muscarinic receptors
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Pharmacology

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