Role of the M                         1                          receptor in regulating circadian rhythms

Martha U. Gillette; Gordon F. Buchanan; Liana Artinian; Susan E. Hamilton; Neil M. Nathanson; Chen Liu

doi:10.1016/S0024-3205(01)01040-2

Role of the M ₁ receptor in regulating circadian rhythms

Martha U. Gillette, Gordon F. Buchanan, Liana Artinian, Susan E. Hamilton, Neil M. Nathanson, Chen Liu

Research output: Contribution to journal › Article › peer-review

Abstract

Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M₁-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.

Original language	English (US)
Pages (from-to)	2467-2472
Number of pages	6
Journal	Life Sciences
Volume	68
Issue number	22-23
DOIs	https://doi.org/10.1016/S0024-3205(01)01040-2
State	Published - Apr 27 2001

Keywords

Acetylcholine
cGMP/PKG signaling
Circadian rhythms
Muscarinic receptors
Suprachiasmatic nucleus

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/S0024-3205(01)01040-2

Fingerprint Dive into the research topics of 'Role of the M <sub>1</sub> receptor in regulating circadian rhythms'. Together they form a unique fingerprint.

Cite this

Role of the M ₁ receptor in regulating circadian rhythms . / Gillette, Martha U.; Buchanan, Gordon F.; Artinian, Liana; Hamilton, Susan E.; Nathanson, Neil M.; Liu, Chen.

In: Life Sciences, Vol. 68, No. 22-23, 27.04.2001, p. 2467-2472.

Research output: Contribution to journal › Article › peer-review

@article{4a5d87716a6742d2994a0199f05646ba,

title = " Role of the M 1 receptor in regulating circadian rhythms ",

abstract = "Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.",

keywords = "Acetylcholine, cGMP/PKG signaling, Circadian rhythms, Muscarinic receptors, Suprachiasmatic nucleus",

author = "Gillette, {Martha U.} and Buchanan, {Gordon F.} and Liana Artinian and Hamilton, {Susan E.} and Nathanson, {Neil M.} and Chen Liu",

note = "Funding Information: This work was supported by NIH grants PHS Grants NS35859 (MUG), GM07143 (GFB) and NS26920(NMN).",

year = "2001",

month = apr,

day = "27",

doi = "10.1016/S0024-3205(01)01040-2",

language = "English (US)",

volume = "68",

pages = "2467--2472",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "22-23",

}

TY - JOUR

T1 - Role of the M 1 receptor in regulating circadian rhythms

AU - Gillette, Martha U.

AU - Buchanan, Gordon F.

AU - Artinian, Liana

AU - Hamilton, Susan E.

AU - Nathanson, Neil M.

AU - Liu, Chen

N1 - Funding Information: This work was supported by NIH grants PHS Grants NS35859 (MUG), GM07143 (GFB) and NS26920(NMN).

PY - 2001/4/27

Y1 - 2001/4/27

N2 - Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.

AB - Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.

KW - Acetylcholine

KW - cGMP/PKG signaling

KW - Circadian rhythms

KW - Muscarinic receptors

KW - Suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=0035957502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035957502&partnerID=8YFLogxK

U2 - 10.1016/S0024-3205(01)01040-2

DO - 10.1016/S0024-3205(01)01040-2

M3 - Article

C2 - 11392614

AN - SCOPUS:0035957502

VL - 68

SP - 2467

EP - 2472

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 22-23

ER -