Abstract
Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.
Original language | English (US) |
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Pages (from-to) | 2467-2472 |
Number of pages | 6 |
Journal | Life Sciences |
Volume | 68 |
Issue number | 22-23 |
DOIs | |
State | Published - Apr 27 2001 |
Keywords
- Acetylcholine
- cGMP/PKG signaling
- Circadian rhythms
- Muscarinic receptors
- Suprachiasmatic nucleus
ASJC Scopus subject areas
- Pharmacology