Role of the M                         1                          receptor in regulating circadian rhythms

Martha U. Gillette; Gordon F. Buchanan; Liana Artinian; Susan E. Hamilton; Neil M. Nathanson; Chen Liu

doi:10.1016/S0024-3205(01)01040-2

Role of the M ₁ receptor in regulating circadian rhythms

Martha U. Gillette, Gordon F. Buchanan, Liana Artinian, Susan E. Hamilton, Neil M. Nathanson, Chen Liu

Research output: Contribution to journal › Article › peer-review

Abstract

Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M₁-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.

Original language	English (US)
Pages (from-to)	2467-2472
Number of pages	6
Journal	Life Sciences
Volume	68
Issue number	22-23
DOIs	https://doi.org/10.1016/S0024-3205(01)01040-2
State	Published - Apr 27 2001

Keywords

Acetylcholine
cGMP/PKG signaling
Circadian rhythms
Muscarinic receptors
Suprachiasmatic nucleus

ASJC Scopus subject areas

Pharmacology

Online availability

10.1016/S0024-3205(01)01040-2

Library availability

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Cite this

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title = " Role of the M 1 receptor in regulating circadian rhythms ",

abstract = "Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.",

keywords = "Acetylcholine, cGMP/PKG signaling, Circadian rhythms, Muscarinic receptors, Suprachiasmatic nucleus",

author = "Gillette, {Martha U.} and Buchanan, {Gordon F.} and Liana Artinian and Hamilton, {Susan E.} and Nathanson, {Neil M.} and Chen Liu",

note = "This work was supported by NIH grants PHS Grants NS35859 (MUG), GM07143 (GFB) and NS26920(NMN).",

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T1 - Role of the M 1 receptor in regulating circadian rhythms

AU - Gillette, Martha U.

AU - Buchanan, Gordon F.

AU - Artinian, Liana

AU - Hamilton, Susan E.

AU - Nathanson, Neil M.

AU - Liu, Chen

N1 - This work was supported by NIH grants PHS Grants NS35859 (MUG), GM07143 (GFB) and NS26920(NMN).

PY - 2001/4/27

Y1 - 2001/4/27

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AB - Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.

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KW - Circadian rhythms

KW - Muscarinic receptors

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