Role of the M                         1                          receptor in regulating circadian rhythms

Martha U. Gillette; Gordon F. Buchanan; Liana Artinian; Susan E. Hamilton; Neil M. Nathanson; Chen Liu

doi:10.1016/S0024-3205(01)01040-2

Role of the M ₁ receptor in regulating circadian rhythms

Martha U. Gillette, Gordon F. Buchanan, Liana Artinian, Susan E. Hamilton, Neil M. Nathanson, Chen Liu

Research output: Contribution to journal › Article › peer-review

Abstract

Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M₁-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.

Original language	English (US)
Pages (from-to)	2467-2472
Number of pages	6
Journal	Life Sciences
Volume	68
Issue number	22-23
DOIs	https://doi.org/10.1016/S0024-3205(01)01040-2
State	Published - Apr 27 2001

Keywords

Acetylcholine
cGMP/PKG signaling
Circadian rhythms
Muscarinic receptors
Suprachiasmatic nucleus

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/S0024-3205(01)01040-2

Cite this

Role of the M ₁ receptor in regulating circadian rhythms . / Gillette, Martha U.; Buchanan, Gordon F.; Artinian, Liana; Hamilton, Susan E.; Nathanson, Neil M.; Liu, Chen.

In: Life Sciences, Vol. 68, No. 22-23, 27.04.2001, p. 2467-2472.

Research output: Contribution to journal › Article › peer-review

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AU - Nathanson, Neil M.

AU - Liu, Chen

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