Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.

Original languageEnglish (US)
Pages (from-to)2467-2472
Number of pages6
JournalLife Sciences
Issue number22-23
StatePublished - Apr 27 2001


  • Acetylcholine
  • cGMP/PKG signaling
  • Circadian rhythms
  • Muscarinic receptors
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Pharmacology


Dive into the research topics of 'Role of the M 1 receptor in regulating circadian rhythms'. Together they form a unique fingerprint.

Cite this