Role of the lymphatics in cancer metastasis and chemotherapy applications

Jennifer D. McAllaster, Mark S. Cohen

Research output: Contribution to journalReview articlepeer-review

Abstract

The lymphatic system was first described centuries ago. The recent discovery of various molecular markers has allowed for more in-depth research of the lymphatic system and its role in health and disease. The lymphatic system has recently been elucidated as playing an active role in cancer metastasis. The knowledge of the active processes involved in lymphatic metastasis provides novel treatment targets for various malignancies.

Original languageEnglish (US)
Pages (from-to)867-875
Number of pages9
JournalAdvanced Drug Delivery Reviews
Volume63
Issue number10-11
DOIs
StatePublished - Sep 10 2011
Externally publishedYes

Keywords

  • Lymphangiogenesis
  • Lymphatic anatomy
  • Lymphatic endothelial cells
  • Lymphatic metastasis
  • Lymphatic vasculature
  • Vascular endothelial growth factors

ASJC Scopus subject areas

  • Pharmaceutical Science

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