Role of the Helicobacter pylori-Induced inflammatory response in the development of gastric cancer

Acacia Lamb, Lin Feng Chen

Research output: Contribution to journalReview article

Abstract

Helicobacter pylori (H. pylori) infection causes chronic gastritis and peptic ulceration and is the strongest risk factor for the development of gastric cancer. The pathogenesis of H. pylori is believed to be associated with infection-initiated chronic gastritis, which is characterized by enhanced expression of many inflammatory genes. H. pylori utilizes various virulence factors, targeting different cellular proteins, to modulate the host inflammatory response. In this review, we explore the many different ways by which H. pylori initiates inflammation, leveling many "hits" on the gastric mucosa which can lead to the development of cancer. We also discuss some recent findings in understanding the pathogen-host interactions and the role of transcription factor NF-κB in H. pylori-induced inflammation. J. Cell. Biochem. 114: 491-497, 2013.

Original languageEnglish (US)
Pages (from-to)491-497
Number of pages7
JournalJournal of Cellular Biochemistry
Volume114
Issue number3
DOIs
StatePublished - Mar 1 2013

Keywords

  • GASTRIC CANCER
  • Helicobacter pylori
  • INFLAMMATION
  • NF-κB

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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