Role of omega-3 and omega-6 endocannabinoids in cardiopulmonary pharmacology

Tiffany Y.C. Tang, Justin S. Kim, Aditi Das

Research output: Chapter in Book/Report/Conference proceedingChapter


Endocannabinoids are derived from dietary omega-3 and omega-6 fatty acids and play an important role in regulation of inflammation, development, neurodegenerative diseases, cancer, and cardiovascular diseases. They elicit this effect via interactions with cannabinoid receptors 1 and 2 which are also targeted by plant derived cannabinoid from cannabis. The evidence of the involvement of the endocannabinoid system in cardiopulmonary function comes from studies that show that cannabis consumption leads to cardiovascular effect such as arrythmia and is beneficial in lung cancer patients. Moreover, omega-3 and omega-6 endocannabinoids play several important roles in cardiopulmonary system such as causing airway relaxation, suppressing atherosclerosis and hypertension. These effects are mediated via the cannabinoids receptors that are abundant in the cardiopulmonary system. Overall, this chapter reviews the known role of phytocannabinoids and endocannabinoids in the cardiopulmonary context.

Original languageEnglish (US)
Title of host publicationBioactive Lipid Mediators in Cardiopulmonary Pharmacology
EditorsDarryl C. Zeldin, John M. Seubert
PublisherAcademic Press Inc.
Number of pages48
ISBN (Print)9780323950572
StatePublished - Jan 2023

Publication series

NameAdvances in Pharmacology
ISSN (Print)1054-3589
ISSN (Electronic)1557-8925


  • Asthma
  • Coronary artery disease
  • Hypertension
  • Inflammation
  • Lipid metabolites
  • Omega-3 endocannabinoids
  • Omega-6 endocannabinoids
  • PUFAs

ASJC Scopus subject areas

  • Pharmacology


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