Role of lymphoid/mucosa-associated lymphoid tissue markers in toxicological immunohistochemistry

Kuldeep Singh, Elizabeth Ann Driskell, Adam Wayne Stern

Research output: Chapter in Book/Report/Conference proceedingChapter


The lymphatic system is a vascular system that drains interstitial fluid to the regional lymph nodes and finally to the venous system as lymph. There are primary lymphoid organs which are sites at which B and T lymphocytes are formed, and secondary lymphoid organs are the sites where mature lymphocytes home after exiting primary lymphoid organs and undergo selection and clonal expansion in an antigen-dependent fashion. Primary and secondary lymphoid organs include the bone, thymus, spleen, lymph nodes, and mucosa-associated lymphoid tissue (MALT). There are numerous incidental- or treatment-related degenerate, hyperplastic, neoplastic, inflammatory, and toxicologic lesions observed in these lymphoid organs. This chapter describes these lesions in detail along with various immunohistochemical markers used in labeling lymphocytes and other cells.

Original languageEnglish (US)
Title of host publicationTechnical Aspects of Toxicological Immunohistochemistry
Subtitle of host publicationSystem Specific Biomarkers
Number of pages14
ISBN (Electronic)9781493915163
ISBN (Print)9781493915156
StatePublished - Jan 1 2015


  • Angiectasis
  • Hyperplasia
  • Immunohistochemistry
  • Lymphosarcoma
  • MALT
  • Toxicologic lesions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Agricultural and Biological Sciences(all)


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