Role of BMK1 in regulation of growth factor-induced cellular responses

Y. Kato, T. H. Chao, M. Hayashi, Richard I Tapping, J. D. Lee

    Research output: Contribution to journalArticlepeer-review


    Big mitogen-activated protein kinase (MAPK) 1 (BMK1), also known as ERK5, is a recently identified member of the mammalian MAPK family. Cellular stimulation of BMK1 is induced in response to growth factors, oxidative stress, and hyperosmolar conditions. Specific members of the myocyte enhancer factor 2 family of transcription factors that regulate growth factor-induced early gene expression have been identified as direct downstream targets of BMK1 activity. Recent studies have shown that growth factors of the epidermal growth factor family mediate the sequential activation of a kinase cascade consisting of MAPK kinase kinase 3, MAPK kinase 5, and BMK1. Most importantly, the activation of this signal transduction pathway has been shown to be required for growth factor-mediated cell proliferation and cell-cycle progression. Collectively, these studies establish BMK1 as an important regulator of growth factor-induced cellular responses.

    Original languageEnglish (US)
    Pages (from-to)233-237
    Number of pages5
    JournalImmunologic Research
    Issue number2-3
    StatePublished - Sep 18 2000


    • Cell cycle
    • Cell proliferation
    • Growth factor
    • Intracellular signaling
    • Protein kinase

    ASJC Scopus subject areas

    • Immunology


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