Abstract
The rates of synthesis of total RNA, poly(A)+ RNA and poly(A)+ RNA are decreased by 41, 49 and 42%, respectively, in hepatocytes isolated from senescent (25 months) compared to adult (12 months) female Wistar rats. Results from transcription run-on assays indicate that an impaired ability to initiate transcription largely accounts for the decreased synthesis of RNA by the senescent hepatocytes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 76-83 |
| Number of pages | 8 |
| Journal | Gerontology |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1990 |
Keywords
- Hepatocytes
- RNA synthesis
- Transcription rate
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology
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