RNA synthesis by hepatocytes isolated from adult and senescent wistar rat liver

G. H. Park; D. E. Buetow

doi:10.1159/000213180

RNA synthesis by hepatocytes isolated from adult and senescent wistar rat liver

G. H. Park, D. E. Buetow

Molecular and Integrative Physiology

Research output: Contribution to journal › Article › peer-review

Abstract

The rates of synthesis of total RNA, poly(A)⁺ RNA and poly(A)⁺ RNA are decreased by 41, 49 and 42%, respectively, in hepatocytes isolated from senescent (25 months) compared to adult (12 months) female Wistar rats. Results from transcription run-on assays indicate that an impaired ability to initiate transcription largely accounts for the decreased synthesis of RNA by the senescent hepatocytes.

Original language	English (US)
Pages (from-to)	76-83
Number of pages	8
Journal	Gerontology
Volume	36
Issue number	2
DOIs	https://doi.org/10.1159/000213180
State	Published - 1990

Keywords

Hepatocytes
RNA synthesis
Transcription rate

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

Online availability

10.1159/000213180

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abstract = "The rates of synthesis of total RNA, poly(A)+ RNA and poly(A)+ RNA are decreased by 41, 49 and 42%, respectively, in hepatocytes isolated from senescent (25 months) compared to adult (12 months) female Wistar rats. Results from transcription run-on assays indicate that an impaired ability to initiate transcription largely accounts for the decreased synthesis of RNA by the senescent hepatocytes.",

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AU - Buetow, D. E.

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AB - The rates of synthesis of total RNA, poly(A)+ RNA and poly(A)+ RNA are decreased by 41, 49 and 42%, respectively, in hepatocytes isolated from senescent (25 months) compared to adult (12 months) female Wistar rats. Results from transcription run-on assays indicate that an impaired ability to initiate transcription largely accounts for the decreased synthesis of RNA by the senescent hepatocytes.

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KW - RNA synthesis

KW - Transcription rate

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RNA synthesis by hepatocytes isolated from adult and senescent wistar rat liver

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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