RNA synthesis by hepatocytes isolated from adult and senescent wistar rat liver

G. H. Park, D. E. Buetow

Research output: Contribution to journalArticlepeer-review

Abstract

The rates of synthesis of total RNA, poly(A)+ RNA and poly(A)+ RNA are decreased by 41, 49 and 42%, respectively, in hepatocytes isolated from senescent (25 months) compared to adult (12 months) female Wistar rats. Results from transcription run-on assays indicate that an impaired ability to initiate transcription largely accounts for the decreased synthesis of RNA by the senescent hepatocytes.

Original languageEnglish (US)
Pages (from-to)76-83
Number of pages8
JournalGerontology
Volume36
Issue number2
DOIs
StatePublished - Jan 1 1990

Keywords

  • Hepatocytes
  • RNA synthesis
  • Transcription rate

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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