Abstract
MicroRNAs act by post-transcriptionally regulating the gene expression of 30%–60% of mammalian genomes. MicroRNAs are key regulators in all cellular processes, though the mechanism by which the cell activates or represses microRNA-mediated translational regulation is poorly understood. In this review, we discuss the RNA binding protein Fragile X Mental Retardation Protein (FMRP) and its role in microRNA-mediated translational regulation. Historically, FMRP is known to function as a translational suppressor. However, emerging data suggests that FMRP has both an agonistic and antagonistic role in regulating microRNA-mediated translational suppression. This bi-functional role is dependent on FMRP’s interaction with the RNA helicase Moloney leukemia virus 10 (MOV10), which modifies the structural landscape of bound mRNA, therefore facilitating or inhibiting its association with the RNA-Induced Silencing Complex.
Original language | English (US) |
---|---|
Article number | 985 |
Journal | International journal of molecular sciences |
Volume | 17 |
Issue number | 6 |
DOIs | |
State | Published - Jun 22 2016 |
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Keywords
- FMRP
- G-Quadruplex
- MOV10
- RNA binding proteins
- Secondary structure
- microRNA
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
Cite this
RNA secondary structure modulates FMRP’s bi-functional role in the microRNA pathway. / Kenny, Phillip; Ceman, Stephanie.
In: International journal of molecular sciences, Vol. 17, No. 6, 985, 22.06.2016.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - RNA secondary structure modulates FMRP’s bi-functional role in the microRNA pathway
AU - Kenny, Phillip
AU - Ceman, Stephanie
PY - 2016/6/22
Y1 - 2016/6/22
N2 - MicroRNAs act by post-transcriptionally regulating the gene expression of 30%–60% of mammalian genomes. MicroRNAs are key regulators in all cellular processes, though the mechanism by which the cell activates or represses microRNA-mediated translational regulation is poorly understood. In this review, we discuss the RNA binding protein Fragile X Mental Retardation Protein (FMRP) and its role in microRNA-mediated translational regulation. Historically, FMRP is known to function as a translational suppressor. However, emerging data suggests that FMRP has both an agonistic and antagonistic role in regulating microRNA-mediated translational suppression. This bi-functional role is dependent on FMRP’s interaction with the RNA helicase Moloney leukemia virus 10 (MOV10), which modifies the structural landscape of bound mRNA, therefore facilitating or inhibiting its association with the RNA-Induced Silencing Complex.
AB - MicroRNAs act by post-transcriptionally regulating the gene expression of 30%–60% of mammalian genomes. MicroRNAs are key regulators in all cellular processes, though the mechanism by which the cell activates or represses microRNA-mediated translational regulation is poorly understood. In this review, we discuss the RNA binding protein Fragile X Mental Retardation Protein (FMRP) and its role in microRNA-mediated translational regulation. Historically, FMRP is known to function as a translational suppressor. However, emerging data suggests that FMRP has both an agonistic and antagonistic role in regulating microRNA-mediated translational suppression. This bi-functional role is dependent on FMRP’s interaction with the RNA helicase Moloney leukemia virus 10 (MOV10), which modifies the structural landscape of bound mRNA, therefore facilitating or inhibiting its association with the RNA-Induced Silencing Complex.
KW - FMRP
KW - G-Quadruplex
KW - MOV10
KW - RNA binding proteins
KW - Secondary structure
KW - microRNA
UR - http://www.scopus.com/inward/record.url?scp=85015601760&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85015601760&partnerID=8YFLogxK
U2 - 10.3390/ijms17060985
DO - 10.3390/ijms17060985
M3 - Review article
C2 - 27338369
AN - SCOPUS:85015601760
VL - 17
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 6
M1 - 985
ER -