Ring-shaped confocal photoacoustic computed tomography for small-animal whole-body imaging

Jun Xia, Muhammad Chatni, Konstantin Maslov, Zijian Guo, Mark Anastasio, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We report herein a novel three-dimensional photoacoustic computed tomography (PACT) system for small-animal whole-body imaging. The PACT system, based on a 512-element full-ring ultrasonic transducer array, was cylindrically focused and capable of forming a two-dimensional image in 1.6 seconds. The pulsed laser could either illuminate directly from the top or be reshaped to illuminate the sample from the side. Top illumination was mainly used for mouse brain and mouse embryo imaging. Side illumination provided in vivo anatomical images of an adult mouse. By translating the mouse along the elevational direction, the system provided serial cross-sectional images.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2012
StatePublished - Apr 9 2012
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2012 - San Francisco, CA, United States
Duration: Jan 22 2012Jan 24 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2012
Country/TerritoryUnited States
CitySan Francisco, CA


  • Focal-line image reconstruction
  • Photoacoustic computed tomography
  • Small-animal imaging
  • Whole-body imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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