Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era

Research output: Contribution to journalReview article

Abstract

In the past 15 years, the cost of sequencing a genome has plummeted. Consequently, the number of sequenced bacterial genomes has exponentially increased, and methods for natural product discovery have evolved rapidly to take advantage of the wealth of genomic data. This review highlights applications of genome mining software to compare and organize large-scale data sets and methods for identifying unique biosynthetic pathways amongst the thousands of ribosomally synthesized and post-translationally modified peptide (RiPP) gene clusters. We also discuss a small number of the many RiPPs discovered in the years 2014–2016.

Original languageEnglish (US)
Pages (from-to)36-44
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume38
DOIs
StatePublished - Jun 1 2017

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Biological Products
Genes
Genome
Bacterial Genomes
Peptides
Biosynthetic Pathways
Multigene Family
Software
Costs and Cost Analysis
Costs
Datasets

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

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abstract = "In the past 15 years, the cost of sequencing a genome has plummeted. Consequently, the number of sequenced bacterial genomes has exponentially increased, and methods for natural product discovery have evolved rapidly to take advantage of the wealth of genomic data. This review highlights applications of genome mining software to compare and organize large-scale data sets and methods for identifying unique biosynthetic pathways amongst the thousands of ribosomally synthesized and post-translationally modified peptide (RiPP) gene clusters. We also discuss a small number of the many RiPPs discovered in the years 2014–2016.",
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