TY - JOUR
T1 - Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era
AU - Hetrick, Kenton J.
AU - van der Donk, Wilfred A.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/6/1
Y1 - 2017/6/1
N2 - In the past 15 years, the cost of sequencing a genome has plummeted. Consequently, the number of sequenced bacterial genomes has exponentially increased, and methods for natural product discovery have evolved rapidly to take advantage of the wealth of genomic data. This review highlights applications of genome mining software to compare and organize large-scale data sets and methods for identifying unique biosynthetic pathways amongst the thousands of ribosomally synthesized and post-translationally modified peptide (RiPP) gene clusters. We also discuss a small number of the many RiPPs discovered in the years 2014–2016.
AB - In the past 15 years, the cost of sequencing a genome has plummeted. Consequently, the number of sequenced bacterial genomes has exponentially increased, and methods for natural product discovery have evolved rapidly to take advantage of the wealth of genomic data. This review highlights applications of genome mining software to compare and organize large-scale data sets and methods for identifying unique biosynthetic pathways amongst the thousands of ribosomally synthesized and post-translationally modified peptide (RiPP) gene clusters. We also discuss a small number of the many RiPPs discovered in the years 2014–2016.
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U2 - 10.1016/j.cbpa.2017.02.005
DO - 10.1016/j.cbpa.2017.02.005
M3 - Review article
C2 - 28260651
AN - SCOPUS:85014284982
SN - 1367-5931
VL - 38
SP - 36
EP - 44
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
ER -