Ribosomally synthesized and post-translationally modified peptide natural products: New insights into the role of leader and core peptides during biosynthesis

Research output: Contribution to journalArticle

Abstract

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a major class of natural products with a high degree of structural diversity and a wide variety of bioactivities. Understanding the biosynthetic machinery of these RiPPs will benefit the discovery and development of new molecules with potential pharmaceutical applications. In this Concept article, we discuss the features of the biosynthetic pathways to different RiPP classes, and propose mechanisms regarding recognition of the precursor peptide by the post-translational modification enzymes. We propose that the leader peptides function as allosteric regulators that bind the active form of the biosynthetic enzymes in a conformational selection process. We also speculate how enzymes that generate polycyclic products of defined topologies may have been selected for during evolution.

Original languageEnglish (US)
Pages (from-to)7662-7677
Number of pages16
JournalChemistry - A European Journal
Volume19
Issue number24
DOIs
StatePublished - Jun 10 2013

Keywords

  • biosynthesis
  • natural products
  • peptides
  • protein modifications

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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