Ribonucleotide reductases: radical enzymes with suicidal tendencies

Jo Anne Stubbe, Wilfred A. van der Donk

Research output: Contribution to journalReview articlepeer-review


Ribonucletide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents.

Original languageEnglish (US)
Pages (from-to)793-801
Number of pages9
JournalChemistry and Biology
Issue number12
StatePublished - Dec 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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