Ribonucleotide reductases: radical enzymes with suicidal tendencies

Jo Anne Stubbe; Wilfred A. van der Donk

doi:10.1016/1074-5521(95)90084-5

Ribonucleotide reductases: radical enzymes with suicidal tendencies

Research output: Contribution to journal › Review article › peer-review

Abstract

Ribonucletide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents.

Original language	English (US)
Pages (from-to)	793-801
Number of pages	9
Journal	Chemistry and Biology
Volume	2
Issue number	12
DOIs	https://doi.org/10.1016/1074-5521(95)90084-5
State	Published - Dec 1995
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/1074-5521(95)90084-5

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abstract = "Ribonucletide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents.",

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year = "1995",

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AB - Ribonucletide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents.

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Ribonucleotide reductases: radical enzymes with suicidal tendencies

Abstract

ASJC Scopus subject areas

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