Ribonucleotide reductases: radical enzymes with suicidal tendencies

Jo Anne Stubbe, Wilfred A. van der Donk

Research output: Contribution to journalReview article

Abstract

Ribonucletide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents.

Original languageEnglish (US)
Pages (from-to)793-801
Number of pages9
JournalChemistry and Biology
Volume2
Issue number12
DOIs
StatePublished - Dec 1995
Externally publishedYes

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Ribonucleotide Reductases
Biochemistry
Biosynthesis
Antineoplastic Agents
Antiviral Agents
Oxidoreductases
Nucleotides
DNA
Enzymes
Proteins

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Ribonucleotide reductases : radical enzymes with suicidal tendencies. / Stubbe, Jo Anne; van der Donk, Wilfred A.

In: Chemistry and Biology, Vol. 2, No. 12, 12.1995, p. 793-801.

Research output: Contribution to journalReview article

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