Rhodium-Catalyzed oxidative amidation of sterically hindered aldehydes and alcohols

Trang T. Nguyen, Kami L. Hull

Research output: Contribution to journalArticlepeer-review

Abstract

A rhodium-catalyzed oxidative amidation reaction has been developed with sterically hindered aldehydes and alcohols for the synthesis of amides containing a quaternary carbon at the α position. A variety of amine nucleophiles, both aliphatic and aromatic, are employed and afford the corresponding amides in good to excellent yields. Finally, mechanistic studies are performed to gain insight into both catalytic cycles.

Original languageEnglish (US)
JournalACS Catalysis
Volume6
Issue number12
DOIs
StatePublished - Dec 2 2016

Keywords

  • Amidation
  • Amine
  • Aniline
  • Hindered
  • Oxidation
  • Rhodium

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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