Rheology of gastric mucin exhibits a pH-dependent sol-gel transition

Jonathan P. Celli, Bradley S. Turner, Nezam H. Afdhal, Randy H. Ewoldt, Gareth H. McKinley, Rama Bansil, Shyamsunder Erramilli, Shyamsunder Erramilli

Research output: Contribution to journalArticlepeer-review

Abstract

Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution at neutral pH to a soft viscoelastic gel in acidic conditions, with the transition occurring near pH 4. In addition to pH-dependent gelation behavior in this system, further rheological studies under nonlinear deformations reveal shear thinning and an apparent yield stress in this material which are also highly influenced by pH.

Original languageEnglish (US)
Pages (from-to)1580-1586
Number of pages7
JournalBiomacromolecules
Volume8
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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