TY - JOUR
T1 - Rheological behavior of living cells is timescale-dependent
AU - Stamenović, Dimitrije
AU - Rosenblatt, Noah
AU - Montoya-Zavala, Martín
AU - Matthews, Benjamin D.
AU - Hu, Shaohua
AU - Suki, Béla
AU - Wang, Ning
AU - Ingber, Donald E.
N1 - This work was supported by National Institutes of Health grant Nos. HL33009, GM072744, and CA55833.
PY - 2007/10
Y1 - 2007/10
N2 - The dynamic mechanical behavior of living cells has been proposed to result from timescale-invariant processes governed by the soft glass rheology theory derived from soft matter physics. But this theory is based on experimental measurements over timescales that are shorter than those most relevant for cell growth and function. Here we report results measured over a wider range of timescales which demonstrate that rheological behaviors of living cells are not timescale-invariant. These findings demonstrate that although soft glass rheology appears to accurately predict certain cell mechanical behaviors, it is not a unified model of cell rheology under biologically relevant conditions and thus, alternative mechanisms need to be considered.
AB - The dynamic mechanical behavior of living cells has been proposed to result from timescale-invariant processes governed by the soft glass rheology theory derived from soft matter physics. But this theory is based on experimental measurements over timescales that are shorter than those most relevant for cell growth and function. Here we report results measured over a wider range of timescales which demonstrate that rheological behaviors of living cells are not timescale-invariant. These findings demonstrate that although soft glass rheology appears to accurately predict certain cell mechanical behaviors, it is not a unified model of cell rheology under biologically relevant conditions and thus, alternative mechanisms need to be considered.
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U2 - 10.1529/biophysj.107.116582
DO - 10.1529/biophysj.107.116582
M3 - Article
C2 - 17693464
AN - SCOPUS:35348965114
SN - 0006-3495
VL - 93
SP - L39-L41
JO - Biophysical journal
JF - Biophysical journal
IS - 8
ER -