Reward anticipation and punishment anticipation are instantiated in the brain via opponent mechanisms

Jessica I. Lake, Jeffrey M. Spielberg, Zachary P. Infantolino, Laura D. Crocker, Cindy M. Yee, Wendy Heller, Gregory A. Miller

Research output: Contribution to journalArticle

Abstract

fMRI investigations have examined the extent to which reward and punishment motivation are associated with common or opponent neural systems, but such investigations have been limited by confounding variables and methodological constraints. The present study aimed to address limitations of earlier approaches and more comprehensively evaluate the extent to which neural activation associated with reward and punishment motivation reflects opponent or shared systems. Participants completed a modified monetary incentive delay task, which involved the presentation of a cue followed by a target to which participants were required to make a speeded button press. Using a factorial design, cues indicated whether monetary reward and/or loss (i.e., cues signaled probability of reward, punishment, both, or neither) could be expected depending upon response speed. Neural analyses evaluated evidence of (a) directionally opposing effects by testing for regions of differential activation for reward and punishment anticipation, (b) mutual inhibition by testing for interactive effects of reward and punishment anticipation within a factorial design, and (c) opposing effects on shared outputs via a psychophysiological interaction analysis. Evidence supporting all three criteria for opponent systems was obtained. Collectively, present findings support conceptualizing reward and punishment motivation as opponent forces influencing brain and behavior and indicate that shared activation does not suggest the operation of a common neural mechanism instantiating reward and punishment motivation.

Original languageEnglish (US)
Article numbere13381
JournalPsychophysiology
Volume56
Issue number8
DOIs
StatePublished - Aug 2019

Fingerprint

Punishment
Reward
Brain
Motivation
Cues
Confounding Factors (Epidemiology)
Magnetic Resonance Imaging

Keywords

  • dACC
  • fMRI
  • punishment
  • reward
  • salience
  • valence

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Endocrine and Autonomic Systems
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Biological Psychiatry

Cite this

Lake, J. I., Spielberg, J. M., Infantolino, Z. P., Crocker, L. D., Yee, C. M., Heller, W., & Miller, G. A. (2019). Reward anticipation and punishment anticipation are instantiated in the brain via opponent mechanisms. Psychophysiology, 56(8), [e13381]. https://doi.org/10.1111/psyp.13381

Reward anticipation and punishment anticipation are instantiated in the brain via opponent mechanisms. / Lake, Jessica I.; Spielberg, Jeffrey M.; Infantolino, Zachary P.; Crocker, Laura D.; Yee, Cindy M.; Heller, Wendy; Miller, Gregory A.

In: Psychophysiology, Vol. 56, No. 8, e13381, 08.2019.

Research output: Contribution to journalArticle

Lake, JI, Spielberg, JM, Infantolino, ZP, Crocker, LD, Yee, CM, Heller, W & Miller, GA 2019, 'Reward anticipation and punishment anticipation are instantiated in the brain via opponent mechanisms', Psychophysiology, vol. 56, no. 8, e13381. https://doi.org/10.1111/psyp.13381
Lake, Jessica I. ; Spielberg, Jeffrey M. ; Infantolino, Zachary P. ; Crocker, Laura D. ; Yee, Cindy M. ; Heller, Wendy ; Miller, Gregory A. / Reward anticipation and punishment anticipation are instantiated in the brain via opponent mechanisms. In: Psychophysiology. 2019 ; Vol. 56, No. 8.
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