Abstract
Studies of catalytically active DNA sequences have expanded considerably since the first artificial deoxyribozyme was identified in 1994. Nevertheless, the field is still quite young, and advances in both fundamental understanding and practical applications of deoxyribozymes are still developing. Deoxyribozymes that either cleave or ligate two RNA substrates have been most widely investigated, and this review describes recent advances in the fundamental studies and applications of these DNA enzymes. Deoxyribozymes with catalytic activities other than RNA ligation and cleavage are also increasingly pursued, and this review covers several key examples.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 279-292 |
| Number of pages | 14 |
| Journal | Biopolymers |
| Volume | 87 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - Dec 5 2007 |
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Keywords
- Cleavage
- DNA enzyme
- DNAzyme
- Deoxyribozyme
- Ligation
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Biomaterials
- Organic Chemistry
Cite this
Review : Recent advances in DNA catalysis. / Höbartner, Claudia; Silverman, Scott K.
In: Biopolymers, Vol. 87, No. 5-6, 05.12.2007, p. 279-292.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Review
T2 - Recent advances in DNA catalysis
AU - Höbartner, Claudia
AU - Silverman, Scott K.
PY - 2007/12/5
Y1 - 2007/12/5
N2 - Studies of catalytically active DNA sequences have expanded considerably since the first artificial deoxyribozyme was identified in 1994. Nevertheless, the field is still quite young, and advances in both fundamental understanding and practical applications of deoxyribozymes are still developing. Deoxyribozymes that either cleave or ligate two RNA substrates have been most widely investigated, and this review describes recent advances in the fundamental studies and applications of these DNA enzymes. Deoxyribozymes with catalytic activities other than RNA ligation and cleavage are also increasingly pursued, and this review covers several key examples.
AB - Studies of catalytically active DNA sequences have expanded considerably since the first artificial deoxyribozyme was identified in 1994. Nevertheless, the field is still quite young, and advances in both fundamental understanding and practical applications of deoxyribozymes are still developing. Deoxyribozymes that either cleave or ligate two RNA substrates have been most widely investigated, and this review describes recent advances in the fundamental studies and applications of these DNA enzymes. Deoxyribozymes with catalytic activities other than RNA ligation and cleavage are also increasingly pursued, and this review covers several key examples.
KW - Cleavage
KW - DNA enzyme
KW - DNAzyme
KW - Deoxyribozyme
KW - Ligation
UR - http://www.scopus.com/inward/record.url?scp=37549019376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37549019376&partnerID=8YFLogxK
U2 - 10.1002/bip.20813
DO - 10.1002/bip.20813
M3 - Review article
C2 - 17647280
AN - SCOPUS:37549019376
VL - 87
SP - 279
EP - 292
JO - Biopolymers
JF - Biopolymers
SN - 0006-3525
IS - 5-6
ER -