Review: Recent advances in DNA catalysis

Claudia Höbartner, Scott K. Silverman

Research output: Contribution to journalReview articlepeer-review


Studies of catalytically active DNA sequences have expanded considerably since the first artificial deoxyribozyme was identified in 1994. Nevertheless, the field is still quite young, and advances in both fundamental understanding and practical applications of deoxyribozymes are still developing. Deoxyribozymes that either cleave or ligate two RNA substrates have been most widely investigated, and this review describes recent advances in the fundamental studies and applications of these DNA enzymes. Deoxyribozymes with catalytic activities other than RNA ligation and cleavage are also increasingly pursued, and this review covers several key examples.

Original languageEnglish (US)
Pages (from-to)279-292
Number of pages14
Issue number5-6
StatePublished - Dec 5 2007


  • Cleavage
  • DNA enzyme
  • DNAzyme
  • Deoxyribozyme
  • Ligation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry


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