TY - JOUR
T1 - Review of optical coherence tomography in oncology
AU - Wang, Jianfeng
AU - Xu, Yang
AU - Boppart, Stephen A.
N1 - Funding Information:
We wish to thank all of our colleagues, researchers, and students who have joined us in the pursuit to fundamentally understand the complex process of carcinogenesis, as well as to improve the lives of cancer patients by innovating, developing, and applying the OCT technology. While we have attempted to capture the enormous breadth and depth of research in this area, we apologize that we were not able to fully represent all the impactful papers and results in this continually growing field. Funding to research and write this review was provided in part by the National Institutes of Health (R01 CA213149 and R01 EB023232). Additional information can be found at: http:// biophotonics.illinois.edu.
Publisher Copyright:
© 2017 Society of PhotoOptical Instrumentation Engineers (SPIE).
PY - 2017/12
Y1 - 2017/12
N2 - The application of optical coherence tomography (OCT) in the field of oncology has been prospering over the past decade. OCT imaging has been used to image a broad spectrum of malignancies, including those arising in the breast, brain, bladder, the gastrointestinal, respiratory, and reproductive tracts, the skin, and oral cavity, among others. OCT imaging has initially been applied for guiding biopsies, for intraoperatively evaluating tumor margins and lymph nodes, and for the early detection of small lesions that would often not be visible on gross examination, tasks that align well with the clinical emphasis on early detection and intervention. Recently, OCT imaging has been explored for imaging tumor cells and their dynamics, and for the monitoring of tumor responses to treatments. This paper reviews the evolution of OCT technologies for the clinical application of OCT in surgical and noninvasive interventional oncology procedures and concludes with a discussion of the future directions for OCT technologies, with particular emphasis on their applications in oncology.
AB - The application of optical coherence tomography (OCT) in the field of oncology has been prospering over the past decade. OCT imaging has been used to image a broad spectrum of malignancies, including those arising in the breast, brain, bladder, the gastrointestinal, respiratory, and reproductive tracts, the skin, and oral cavity, among others. OCT imaging has initially been applied for guiding biopsies, for intraoperatively evaluating tumor margins and lymph nodes, and for the early detection of small lesions that would often not be visible on gross examination, tasks that align well with the clinical emphasis on early detection and intervention. Recently, OCT imaging has been explored for imaging tumor cells and their dynamics, and for the monitoring of tumor responses to treatments. This paper reviews the evolution of OCT technologies for the clinical application of OCT in surgical and noninvasive interventional oncology procedures and concludes with a discussion of the future directions for OCT technologies, with particular emphasis on their applications in oncology.
KW - Cancer
KW - Intraoperative
KW - Oncology
KW - Optical coherence tomography
KW - Surgery
KW - Tumor
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UR - http://www.scopus.com/inward/citedby.url?scp=85039783904&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.22.12.121711
DO - 10.1117/1.JBO.22.12.121711
M3 - Review article
C2 - 29274145
AN - SCOPUS:85039783904
SN - 1083-3668
VL - 22
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 12
M1 - 121711
ER -