TY - JOUR
T1 - Review of HIV Self Testing Technologies and Promising Approaches for the Next Generation
AU - Bacon, Amanda
AU - Wang, Weijing
AU - Lee, Hankeun
AU - Umrao, Saurabh
AU - Sinawang, Prima Dewi
AU - Akin, Demir
AU - Khemtonglang, Kodchakorn
AU - Tan, Anqi
AU - Hirshfield, Sabina
AU - Demirci, Utkan
AU - Wang, Xing
AU - Cunningham, Brian T.
N1 - Funding Information:
The authors gratefully acknowledge funding from the National Institutes of Health (R01DA049843, R01AI159454, R01MH100973, R21EB031310, R01AI159454 and RadXRad Program grant U01AA029348) and National Science Foundation (NSF RAPID 20-27778, CBET 20-29215). A.T. acknowledges support from Zhejiang University ZJU-UIUC Joint Research Center (DREMES202001). K.K. acknowledges support from the Fulbright U.S. Student Program by the U.S. Department of State and the Thailand–United States Educational Foundation. P.D.S. acknowledges support from James D. Plummer Graduate Fellowship, EDGE Doctoral Fellowship Program, the Dean’s Office of the Stanford School of Engineering, and the Cancer Imaging and Early Detection Award.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/2/20
Y1 - 2023/2/20
N2 - The ability to self-test for HIV is vital to preventing transmission, particularly when used in concert with HIV biomedical prevention modalities, such as pre-exposure prophylaxis (PrEP). In this paper, we review recent developments in HIV self-testing and self-sampling methods, and the potential future impact of novel materials and methods that emerged through efforts to develop more effective point-of-care (POC) SARS-CoV-2 diagnostics. We address the gaps in existing HIV self-testing technologies, where improvements in test sensitivity, sample-to-answer time, simplicity, and cost are needed to enhance diagnostic accuracy and widespread accessibility. We discuss potential paths toward the next generation of HIV self-testing through sample collection materials, biosensing assay techniques, and miniaturized instrumentation. We discuss the implications for other applications, such as self-monitoring of HIV viral load and other infectious diseases.
AB - The ability to self-test for HIV is vital to preventing transmission, particularly when used in concert with HIV biomedical prevention modalities, such as pre-exposure prophylaxis (PrEP). In this paper, we review recent developments in HIV self-testing and self-sampling methods, and the potential future impact of novel materials and methods that emerged through efforts to develop more effective point-of-care (POC) SARS-CoV-2 diagnostics. We address the gaps in existing HIV self-testing technologies, where improvements in test sensitivity, sample-to-answer time, simplicity, and cost are needed to enhance diagnostic accuracy and widespread accessibility. We discuss potential paths toward the next generation of HIV self-testing through sample collection materials, biosensing assay techniques, and miniaturized instrumentation. We discuss the implications for other applications, such as self-monitoring of HIV viral load and other infectious diseases.
KW - HIV self-testing
KW - HIV viral load
KW - viral testing
KW - biosensor
KW - LFA
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U2 - 10.3390/bios13020298
DO - 10.3390/bios13020298
M3 - Review article
C2 - 36832064
SN - 2079-6374
VL - 13
JO - Biosensors
JF - Biosensors
IS - 2
M1 - 298
ER -