@inproceedings{304ecbdbe24c484396ef1e4a8b48a98a,
title = "Reversing coagulopathy and internal hemorrhage with functionalized nanoparticles",
abstract = "Trauma-induced hemorrhage remains a leading cause of preventable death. Silica nanoparticles (SNPs) - long known for their procoagulant properties - have recently been used as a first-response treatment. Functionalizing SNPs with polyphosphate (polyP) - analogous to the polyP produced by activated platelets to induce clotting - to form SNP-polyP leads to decreased clotting times. The decrease in clotting time is even more apparent when studied under traumatic conditions such as hemodilution and hypothermia. In addition to external treatment, the SNP-polyP particles can be protected with polyethylene glycol (PEG) and targeted to treat internal hemorrhage.",
keywords = "Drug delivery, Hemorrhage, Lethal triad, Polyphosphate, Silica nanoparticles",
author = "Damien Kudela and Anna May-Masnou and Smith, {Stephanie A.} and Gary Braun and Alessia Pallaoro and Tracy Chuong and Morrissey, {James H.} and Stucky, {Galen D.}",
year = "2013",
language = "English (US)",
isbn = "9781482205862",
series = "Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013",
pages = "361--364",
booktitle = "Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013",
note = "Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 ; Conference date: 12-05-2013 Through 16-05-2013",
}