Reversing coagulopathy and internal hemorrhage with functionalized nanoparticles

Damien Kudela, Anna May-Masnou, Stephanie A. Smith, Gary Braun, Alessia Pallaoro, Tracy Chuong, James H. Morrissey, Galen D. Stucky

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Trauma-induced hemorrhage remains a leading cause of preventable death. Silica nanoparticles (SNPs) - long known for their procoagulant properties - have recently been used as a first-response treatment. Functionalizing SNPs with polyphosphate (polyP) - analogous to the polyP produced by activated platelets to induce clotting - to form SNP-polyP leads to decreased clotting times. The decrease in clotting time is even more apparent when studied under traumatic conditions such as hemodilution and hypothermia. In addition to external treatment, the SNP-polyP particles can be protected with polyethylene glycol (PEG) and targeted to treat internal hemorrhage.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Pages361-364
Number of pages4
StatePublished - Aug 9 2013
EventNanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, United States
Duration: May 12 2013May 16 2013

Publication series

NameTechnical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Volume3

Other

OtherNanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
CountryUnited States
CityWashington, DC
Period5/12/135/16/13

Keywords

  • Drug delivery
  • Hemorrhage
  • Lethal triad
  • Polyphosphate
  • Silica nanoparticles

ASJC Scopus subject areas

  • Biotechnology

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  • Cite this

    Kudela, D., May-Masnou, A., Smith, S. A., Braun, G., Pallaoro, A., Chuong, T., Morrissey, J. H., & Stucky, G. D. (2013). Reversing coagulopathy and internal hemorrhage with functionalized nanoparticles. In Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 (pp. 361-364). (Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013; Vol. 3).