Reversible cell-specific drug delivery with aptamer-functionalized liposomes

Zehui Cao; Rong Tong; Abhijit Mishra; Weichen Xu; Gerard C.L. Wong; Jianjun Cheng; Yi Lu

doi:10.1002/anie.200901452

Reversible cell-specific drug delivery with aptamer-functionalized liposomes

Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C.L. Wong, Jianjun Cheng, Yi Lu

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolinaptamer- conjugated, cisplatin-encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF-7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the aptamer as an antidote.

Original language	English (US)
Pages (from-to)	6494-6498
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	35
DOIs	https://doi.org/10.1002/anie.200901452
State	Published - 2009

Keywords

Aptamers
Cisplatin
Drug delivery
Liposomes

ASJC Scopus subject areas

General Chemistry
Catalysis
General Medicine

Online availability

10.1002/anie.200901452

Library availability

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AU - Cao, Zehui

AU - Tong, Rong

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AU - Xu, Weichen

AU - Wong, Gerard C.L.

AU - Cheng, Jianjun

AU - Lu, Yi

PY - 2009

Y1 - 2009

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AB - Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolinaptamer- conjugated, cisplatin-encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF-7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the aptamer as an antidote.

KW - Aptamers

KW - Cisplatin

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Reversible cell-specific drug delivery with aptamer-functionalized liposomes

Abstract

Keywords

ASJC Scopus subject areas

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