Reversible cell-specific drug delivery with aptamer-functionalized liposomes

Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C.L. Wong, Jianjun Cheng, Yi Lu

Research output: Contribution to journalArticlepeer-review

Abstract

Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolinaptamer- conjugated, cisplatin-encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF-7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the aptamer as an antidote.

Original languageEnglish (US)
Pages (from-to)6494-6498
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number35
DOIs
StatePublished - Oct 19 2009

Keywords

  • Aptamers
  • Cisplatin
  • Drug delivery
  • Liposomes

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Fingerprint Dive into the research topics of 'Reversible cell-specific drug delivery with aptamer-functionalized liposomes'. Together they form a unique fingerprint.

Cite this