Reversible cell-specific drug delivery with aptamer-functionalized liposomes

Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C.L. Wong, Jianjun Cheng, Yi Lu

Research output: Contribution to journalArticlepeer-review


Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolinaptamer- conjugated, cisplatin-encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF-7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the aptamer as an antidote.

Original languageEnglish (US)
Pages (from-to)6494-6498
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number35
StatePublished - 2009


  • Aptamers
  • Cisplatin
  • Drug delivery
  • Liposomes

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis
  • General Medicine


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