TY - JOUR
T1 - Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages
AU - Grent-’t-jong, Tineke
AU - Gross, Joachim
AU - Goense, Jozien
AU - Wibral, Michael
AU - Gajwani, Ruchika
AU - Gumley, Andrew I.
AU - Lawrie, Stephen M.
AU - Schwannauer, Matthias
AU - Schultze-Lutter, Frauke
AU - Schröder, Tobias Navarro
AU - Koethe, Dagmar
AU - Leweke, F. Markus
AU - Singer, Wolf
AU - Uhlhaas, Peter J.
N1 - Funding Information:
Dr. Uhlhaas has received research support from Lilly and Lundbeck. The study was supported by the Medical Research Council (MR/L011689/1). We thank Hanna Thune, Christine Gruetzner, Davide Riv-olta and Frances Crabbe for help in the acquisition of MEG/MRI/MRS-data. The investigators also acknowledge the support of the Scottish Mental Health Research Network (http://www.smhrn.org. uk) now called the NHS Research Scotland Mental Health Network (NRS MHN: http://www.nhsre-searchscotland.org.uk/research-areas/mental-health) for providing assistance with participant recruitment, interviews, and cognitive assessments. We would like to thank both the participants and patients who took part in the study and the research assistants of the YouR-study for supporting the recruitment and assessment of CHR-participants.
Publisher Copyright:
© Grent-’t-Jong et al.
PY - 2018/9
Y1 - 2018/9
N2 - We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP-and ScZ-patients showed aberrant spectral power at both low-and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ.
AB - We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP-and ScZ-patients showed aberrant spectral power at both low-and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ.
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U2 - 10.7554/eLife.37799
DO - 10.7554/eLife.37799
M3 - Article
C2 - 30260771
AN - SCOPUS:85054081411
SN - 2050-084X
VL - 7
JO - eLife
JF - eLife
M1 - e37799
ER -