Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages

Tineke Grent-’t-jong, Joachim Gross, Jozien Goense, Michael Wibral, Ruchika Gajwani, Andrew I. Gumley, Stephen M. Lawrie, Matthias Schwannauer, Frauke Schultze-Lutter, Tobias Navarro Schröder, Dagmar Koethe, F. Markus Leweke, Wolf Singer, Peter J. Uhlhaas

Research output: Contribution to journalArticlepeer-review

Abstract

We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP-and ScZ-patients showed aberrant spectral power at both low-and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ.

Original languageEnglish (US)
Article numbere37799
JournaleLife
Volume7
DOIs
StatePublished - Sep 2018
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology

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