Resting-state functional connectivity differentiates anxious apprehension and anxious arousal

Erin N. Burdwood, Zachary P. Infantolino, Laura D. Crocker, Jeffrey M. Spielberg, Marie T. Banich, Gregory A. Miller, Wendy Heller

Research output: Contribution to journalArticle

Abstract

Brain regions in the default mode network (DMN) display greater functional connectivity at rest or during self-referential processing than during goal-directed tasks. The present study assessed resting-state connectivity as a function of anxious apprehension and anxious arousal, independent of depressive symptoms, in order to understand how these dimensions disrupt cognition. Whole-brain, seed-based analyses indicated differences between anxious apprehension and anxious arousal in DMN functional connectivity. Lower connectivity associated with higher anxious apprehension suggests decreased adaptive, inner-focused thought processes, whereas higher connectivity at higher levels of anxious arousal may reflect elevated monitoring of physiological responses to threat. These findings further the conceptualization of anxious apprehension and anxious arousal as distinct psychological dimensions with distinct neural instantiations.

Original languageEnglish (US)
Pages (from-to)1451-1459
Number of pages9
JournalPsychophysiology
Volume53
Issue number10
DOIs
StatePublished - Oct 1 2016

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Arousal
Brain
Physiologic Monitoring
Cognition
Seeds
Depression
Psychology

Keywords

  • Anxiety
  • Psychopathological
  • fMRI/PET/MRI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Neurology
  • Endocrine and Autonomic Systems
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Biological Psychiatry

Cite this

Burdwood, E. N., Infantolino, Z. P., Crocker, L. D., Spielberg, J. M., Banich, M. T., Miller, G. A., & Heller, W. (2016). Resting-state functional connectivity differentiates anxious apprehension and anxious arousal. Psychophysiology, 53(10), 1451-1459. https://doi.org/10.1111/psyp.12696

Resting-state functional connectivity differentiates anxious apprehension and anxious arousal. / Burdwood, Erin N.; Infantolino, Zachary P.; Crocker, Laura D.; Spielberg, Jeffrey M.; Banich, Marie T.; Miller, Gregory A.; Heller, Wendy.

In: Psychophysiology, Vol. 53, No. 10, 01.10.2016, p. 1451-1459.

Research output: Contribution to journalArticle

Burdwood, EN, Infantolino, ZP, Crocker, LD, Spielberg, JM, Banich, MT, Miller, GA & Heller, W 2016, 'Resting-state functional connectivity differentiates anxious apprehension and anxious arousal', Psychophysiology, vol. 53, no. 10, pp. 1451-1459. https://doi.org/10.1111/psyp.12696
Burdwood EN, Infantolino ZP, Crocker LD, Spielberg JM, Banich MT, Miller GA et al. Resting-state functional connectivity differentiates anxious apprehension and anxious arousal. Psychophysiology. 2016 Oct 1;53(10):1451-1459. https://doi.org/10.1111/psyp.12696
Burdwood, Erin N. ; Infantolino, Zachary P. ; Crocker, Laura D. ; Spielberg, Jeffrey M. ; Banich, Marie T. ; Miller, Gregory A. ; Heller, Wendy. / Resting-state functional connectivity differentiates anxious apprehension and anxious arousal. In: Psychophysiology. 2016 ; Vol. 53, No. 10. pp. 1451-1459.
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