A biomimetic hydrogel valve capable of directional flow control in response to the local fluid environment in microfluidic channels is described. The valve consists of a pair of photopolymerized hydrogel bistrips with different pH sensitivities, and becomes activated or deactivated reversibly based on local pH as a result of volume and shape changes. When activated at pH 8, the valve mimics anatomic venous valves both functionally and structurally, allowing fluid flow in one direction under forward pressure while restricting flow in the opposite direction. At an applied pressure of 0.71 psi, the forward flow rate was 140 μL/min, compared to a backward leakage rate of 2.3 μL/min.

Original languageEnglish (US)
Pages (from-to)2589-2591
Number of pages3
JournalApplied Physics Letters
Issue number17
StatePublished - Apr 23 2001

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


Dive into the research topics of 'Responsive biomimetic hydrogel valve for microfluidics'. Together they form a unique fingerprint.

Cite this