Respiratory System

Jack R. Harkema; Kristen J. Nikula; Wanda M. Haschek

doi:10.1016/B978-0-12-415759-0.00051-0

Respiratory System

Jack R. Harkema, Kristen J. Nikula, Wanda M. Haschek

Pathobiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The respiratory tract is a complex organ system both macroscopically and microscopically, with many different functions and cell types localized throughout the nasopharyngeal, tracheobronchial, and pulmonary segments. Exposure to xenobiotics occurs via inhalation and via the blood following ingestion, dermal exposure, or parenteral administration. Xenobiotics vary from particles of variable size to gases to plant toxins, thus dosimetry and site of injury are critical in interpreting the response to injury. In addition, species differences must be considered in interpretation of data to be used in risk assessment. In naturally occurring disease, since the pulmonary response to injury is often non-specific, it is important to consider the gross distribution of pulmonary lesions and to use detailed history and ancillary test results in conjunction with histological evaluation to determine potential etiologic agents. © 2013

Original language	English (US)
Title of host publication	Haschek and Rousseaux's Handbook of Toxicologic Pathology
Editors	Wanda M Haschek, Matthew A Wallig, Colin G Rousseaux
Publisher	Academic Press
Pages	1935-2003
Number of pages	69
Volume	3
Edition	3
ISBN (Electronic)	9780124157590
ISBN (Print)	9780124157651
DOIs	https://doi.org/10.1016/B978-0-12-415759-0.00051-0
State	Published - 2013

Keywords

Inhalation
Lung
Mechanisms
Nose
Pathology
Respiratory tract
Toxicity
Xenobiotics

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics

Online availability

10.1016/B978-0-12-415759-0.00051-0

Library availability

Discover UIUC Full Text

Cite this

@inbook{8d8bb2218c7942e482b13fc004a81d55,

title = "Respiratory System",

abstract = "The respiratory tract is a complex organ system both macroscopically and microscopically, with many different functions and cell types localized throughout the nasopharyngeal, tracheobronchial, and pulmonary segments. Exposure to xenobiotics occurs via inhalation and via the blood following ingestion, dermal exposure, or parenteral administration. Xenobiotics vary from particles of variable size to gases to plant toxins, thus dosimetry and site of injury are critical in interpreting the response to injury. In addition, species differences must be considered in interpretation of data to be used in risk assessment. In naturally occurring disease, since the pulmonary response to injury is often non-specific, it is important to consider the gross distribution of pulmonary lesions and to use detailed history and ancillary test results in conjunction with histological evaluation to determine potential etiologic agents. {\textcopyright} 2013",

keywords = "Inhalation, Lung, Mechanisms, Nose, Pathology, Respiratory tract, Toxicity, Xenobiotics",

author = "Harkema, {Jack R.} and Nikula, {Kristen J.} and Haschek, {Wanda M.}",

year = "2013",

doi = "10.1016/B978-0-12-415759-0.00051-0",

language = "English (US)",

isbn = "9780124157651",

volume = "3",

pages = "1935--2003",

editor = "Haschek, {Wanda M} and Wallig, {Matthew A} and Rousseaux, {Colin G}",

booktitle = "Haschek and Rousseaux's Handbook of Toxicologic Pathology",

publisher = "Academic Press",

address = "United Kingdom",

edition = "3",

}

TY - CHAP

T1 - Respiratory System

AU - Harkema, Jack R.

AU - Nikula, Kristen J.

AU - Haschek, Wanda M.

PY - 2013

Y1 - 2013

N2 - The respiratory tract is a complex organ system both macroscopically and microscopically, with many different functions and cell types localized throughout the nasopharyngeal, tracheobronchial, and pulmonary segments. Exposure to xenobiotics occurs via inhalation and via the blood following ingestion, dermal exposure, or parenteral administration. Xenobiotics vary from particles of variable size to gases to plant toxins, thus dosimetry and site of injury are critical in interpreting the response to injury. In addition, species differences must be considered in interpretation of data to be used in risk assessment. In naturally occurring disease, since the pulmonary response to injury is often non-specific, it is important to consider the gross distribution of pulmonary lesions and to use detailed history and ancillary test results in conjunction with histological evaluation to determine potential etiologic agents. © 2013

AB - The respiratory tract is a complex organ system both macroscopically and microscopically, with many different functions and cell types localized throughout the nasopharyngeal, tracheobronchial, and pulmonary segments. Exposure to xenobiotics occurs via inhalation and via the blood following ingestion, dermal exposure, or parenteral administration. Xenobiotics vary from particles of variable size to gases to plant toxins, thus dosimetry and site of injury are critical in interpreting the response to injury. In addition, species differences must be considered in interpretation of data to be used in risk assessment. In naturally occurring disease, since the pulmonary response to injury is often non-specific, it is important to consider the gross distribution of pulmonary lesions and to use detailed history and ancillary test results in conjunction with histological evaluation to determine potential etiologic agents. © 2013

KW - Inhalation

KW - Lung

KW - Mechanisms

KW - Nose

KW - Pathology

KW - Respiratory tract

KW - Toxicity

KW - Xenobiotics

UR - http://www.scopus.com/inward/record.url?scp=84884060155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884060155&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-415759-0.00051-0

DO - 10.1016/B978-0-12-415759-0.00051-0

M3 - Chapter

AN - SCOPUS:84884060155

SN - 9780124157651

VL - 3

SP - 1935

EP - 2003

BT - Haschek and Rousseaux's Handbook of Toxicologic Pathology

A2 - Haschek, Wanda M

A2 - Wallig, Matthew A

A2 - Rousseaux, Colin G

PB - Academic Press

ER -

Respiratory System

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Haschek and Rousseaux's Handbook of Toxicologic Pathology

Cite this