TY - JOUR
T1 - Resolution of serum aluminum-binding proteins by size-exclusion chromatography
T2 - identification of a new carrier of aluminum in human serum
AU - Favarato, Mosè
AU - Mizzen, Craig A.
AU - McLachlan, Donald R.
N1 - Funding Information:
We thank the Clinical Investigation Unit of Toronto General Hospital for their expert assistance. M.F. was supportedb y a fellowship from the Alzheimer Society of Petersborougha nd Victoria. Financial support was also provided by Parke-Davis Inc. (Italy), the Scottish Rite Charitable Foundation of Canada, and National Health and Welfare Canada.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1992/5/8
Y1 - 1992/5/8
N2 - We have examined the use of TSK-GEL HW 55S for determining the distribution of aluminum in human serum by size-exclusion chromatography (SEC). In comparison to other SEC matrices, this material has less affinity for ionized aluminum and separates serum proteins and their aluminum complexes with greater resolution. This enabled the identification of a previously unknown protein carrier, provisionally called albindin, that binds aluminum with great stability. Albindin appears to be distinct from the previously described aluminum carriers albumin and transferrin and may be important in the pathogenesis of disease secondary to hyperaluminemia.
AB - We have examined the use of TSK-GEL HW 55S for determining the distribution of aluminum in human serum by size-exclusion chromatography (SEC). In comparison to other SEC matrices, this material has less affinity for ionized aluminum and separates serum proteins and their aluminum complexes with greater resolution. This enabled the identification of a previously unknown protein carrier, provisionally called albindin, that binds aluminum with great stability. Albindin appears to be distinct from the previously described aluminum carriers albumin and transferrin and may be important in the pathogenesis of disease secondary to hyperaluminemia.
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U2 - 10.1016/0378-4347(92)80201-Z
DO - 10.1016/0378-4347(92)80201-Z
M3 - Article
C2 - 1400715
AN - SCOPUS:0026579931
SN - 1387-2273
VL - 576
SP - 271
EP - 285
JO - Journal of Chromatography B: Biomedical Sciences and Applications
JF - Journal of Chromatography B: Biomedical Sciences and Applications
IS - 2
ER -