Resolution of serum aluminum-binding proteins by size-exclusion chromatography: identification of a new carrier of aluminum in human serum

Mosè Favarato, Craig A. Mizzen, Donald R. McLachlan

Research output: Contribution to journalArticlepeer-review

Abstract

We have examined the use of TSK-GEL HW 55S for determining the distribution of aluminum in human serum by size-exclusion chromatography (SEC). In comparison to other SEC matrices, this material has less affinity for ionized aluminum and separates serum proteins and their aluminum complexes with greater resolution. This enabled the identification of a previously unknown protein carrier, provisionally called albindin, that binds aluminum with great stability. Albindin appears to be distinct from the previously described aluminum carriers albumin and transferrin and may be important in the pathogenesis of disease secondary to hyperaluminemia.

Original languageEnglish (US)
Pages (from-to)271-285
Number of pages15
JournalJournal of Chromatography B: Biomedical Sciences and Applications
Volume576
Issue number2
DOIs
StatePublished - May 8 1992

ASJC Scopus subject areas

  • Chemistry(all)

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